Difference between revisions of "Endometrium with changes due to selective progesterone receptor modulators"

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'''Endometrium with changes due to selective progesterone receptor modulator''' may mimic [[endometrial hyperplasia]].
'''Selective progesterone receptor modulators''', abbreviated '''SPRMs''', are a class of drugs that block the action of progesterone.  They are used to treat [[uterine fibroids]].<ref name=pmid23018219>{{Cite journal  | last1 = Williams | first1 = AR. | last2 = Bergeron | first2 = C. | last3 = Barlow | first3 = DH. | last4 = Ferenczy | first4 = A. | title = Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate. | journal = Int J Gynecol Pathol | volume = 31 | issue = 6 | pages = 556-69 | month = Nov | year = 2012 | doi = 10.1097/PGP.0b013e318251035b | PMID = 23018219 }}</ref>
'''Selective progesterone receptor modulators''', abbreviated '''SPRMs''', are a class of drugs that block the action of progesterone.  They are used to treat [[uterine fibroids]].<ref name=pmid23018219>{{Cite journal  | last1 = Williams | first1 = AR. | last2 = Bergeron | first2 = C. | last3 = Barlow | first3 = DH. | last4 = Ferenczy | first4 = A. | title = Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate. | journal = Int J Gynecol Pathol | volume = 31 | issue = 6 | pages = 556-69 | month = Nov | year = 2012 | doi = 10.1097/PGP.0b013e318251035b | PMID = 23018219 }}</ref>


Revision as of 23:25, 1 January 2018

Endometrium with changes due to selective progesterone receptor modulator may mimic endometrial hyperplasia.

Selective progesterone receptor modulators, abbreviated SPRMs, are a class of drugs that block the action of progesterone. They are used to treat uterine fibroids.[1]

General

  • Ulipristal - trade name Fibristal.
  • May be used as an emergency contraceptive.[2]

Microscopic

Features:[1]

  • Glandular changes - extensive cystic dilatation.
  • Inactive appearing glandular epithelium or abortive subnuclear vacuolization.
  • Rare mitoses and apoptosis.
  • Abnormal stromal vessels - common.

DDx:

See also

References

  1. ↑ 1.0 1.1 Williams, AR.; Bergeron, C.; Barlow, DH.; Ferenczy, A. (Nov 2012). "Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate.". Int J Gynecol Pathol 31 (6): 556-69. doi:10.1097/PGP.0b013e318251035b. PMID 23018219.
  2. ↑ Whitaker, LH.; Williams, AR.; Critchley, HO. (Aug 2014). "Selective progesterone receptor modulators.". Curr Opin Obstet Gynecol 26 (4): 237-42. doi:10.1097/GCO.0000000000000082. PMID 24950125.
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