Mucinous carcinoma: Difference between revisions

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[[Image:Colonic mucinous adenocarcinoma - low mag.jpg|thumb|right|Colonic mucinous adenocarcinoma. [[H&E stain]].]]
[[Image:Colonic mucinous adenocarcinoma - low mag.jpg|thumb|right|Colonic mucinous adenocarcinoma. [[H&E stain]].]]
[[Image:Mucinous adenocarcinoma of prostate - 2b -- high mag.jpg|thumb|right|[[Mucinous adenocarcinoma of the prostate]] is a rare type of [[prostate cancer]]. [[H&E stain]].]]
[[Image:Mucinous lung adenocarcinoma and airway -- high mag.jpg|right|thumb|Mucinous [[adenocarcinoma of the lung]] is often cytologically bland as can be seen in this image; on the right is benign ciliated epithelium and on the left is mucinous adenocarcinoma. [[H&E stain]].]]
[[Image:Mucinous lung adenocarcinoma and airway -- high mag.jpg|right|thumb|Mucinous [[adenocarcinoma of the lung]] is often cytologically bland as can be seen in this image; on the right is benign ciliated epithelium and on the left is mucinous adenocarcinoma. [[H&E stain]].]]
'''Mucinous carcinoma''', also '''mucinous adenocarcinoma''', is an epithelial neoplasm that produces [[mucin]]. Mucinous carcinoma can arise in a number of sites. It is also known as '''colloid carcinoma'''.<ref>URL: [http://www.merriam-webster.com/dictionary/colloid%20carcinoma http://www.merriam-webster.com/dictionary/colloid%20carcinoma]. Accessed on: 14 February 2014.</ref>
'''Mucinous carcinoma''', also '''mucinous adenocarcinoma''', is an epithelial neoplasm that produces [[mucin]]. Mucinous carcinoma can arise in a number of sites. It is also known as '''colloid carcinoma'''.<ref>URL: [http://www.merriam-webster.com/dictionary/colloid%20carcinoma http://www.merriam-webster.com/dictionary/colloid%20carcinoma]. Accessed on: 14 February 2014.</ref>
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*[[Mucinous breast carcinoma|Breast mucinous carcinoma]] has a better prognosis.
*[[Mucinous breast carcinoma|Breast mucinous carcinoma]] has a better prognosis.
*Colorectal mucinous carcinoma has a worse prognosis.<ref name=pmid22476818>{{Cite journal  | last1 = Hyngstrom | first1 = JR. | last2 = Hu | first2 = CY. | last3 = Xing | first3 = Y. | last4 = You | first4 = YN. | last5 = Feig | first5 = BW. | last6 = Skibber | first6 = JM. | last7 = Rodriguez-Bigas | first7 = MA. | last8 = Cormier | first8 = JN. | last9 = Chang | first9 = GJ. | title = Clinicopathology and Outcomes for Mucinous and Signet Ring Colorectal Adenocarcinoma: Analysis from the National Cancer Data Base. | journal = Ann Surg Oncol | volume =  | issue =  | pages =  | month = Apr | year = 2012 | doi = 10.1245/s10434-012-2321-7 | PMID = 22476818 }}</ref>
*Colorectal mucinous carcinoma has a worse prognosis.<ref name=pmid22476818>{{Cite journal  | last1 = Hyngstrom | first1 = JR. | last2 = Hu | first2 = CY. | last3 = Xing | first3 = Y. | last4 = You | first4 = YN. | last5 = Feig | first5 = BW. | last6 = Skibber | first6 = JM. | last7 = Rodriguez-Bigas | first7 = MA. | last8 = Cormier | first8 = JN. | last9 = Chang | first9 = GJ. | title = Clinicopathology and Outcomes for Mucinous and Signet Ring Colorectal Adenocarcinoma: Analysis from the National Cancer Data Base. | journal = Ann Surg Oncol | volume =  | issue =  | pages =  | month = Apr | year = 2012 | doi = 10.1245/s10434-012-2321-7 | PMID = 22476818 }}</ref>
*May be non-significant in esophagus if adjusted for grade and stage.<ref name=pmid23317610>{{Cite journal  | last1 = Zheng | first1 = DJ. | last2 = Cooke | first2 = DT. | title = A survival comparison of mucin-producing adenocarcinoma of the esophagus to conventional adenocarcinoma after esophagectomy. | journal = Am Surg | volume = 79 | issue = 1 | pages = 49-53 | month = Jan | year = 2013 | doi =  | PMID = 23317610 }}</ref>


===Specific sites===
===Specific sites===
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**May have a consistency similar to ''Jello''.
**May have a consistency similar to ''Jello''.


Image:
===Images===
*[http://www.flickr.com/photos/pulmonary_pathology/3931951819/ Mucinous adenocarcinoma of the lung (flickr.com)].
*[http://www.flickr.com/photos/pulmonary_pathology/3931951819/ Mucinous adenocarcinoma of the lung (flickr.com)].
*[http://www.flickr.com/photos/euthman/482649679/ Ovarian mucinous cystadenocarcinoma (flickr.com/euthman)].
*[http://www.flickr.com/photos/euthman/482649679/ Ovarian mucinous cystadenocarcinoma (flickr.com/euthman)].
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*[[Adenocarcinoma]] with mucinous features - see ''proportion of mucin'' section.
*[[Adenocarcinoma]] with mucinous features - see ''proportion of mucin'' section.
*Other [[myxoid tumours]] - has an exhaustive long DDx.
*Other [[myxoid tumours]] - has an exhaustive long DDx.
===Proportion of mucin===
The criteria for diagnosing "mucinous carcinoma" varies by the anatomical site:
*[[Mucinous prostate carcinoma]]: > 25% of the tumour.<ref name=pmid14976541>{{cite journal |author=Grignon DJ |title=Unusual subtypes of prostate cancer |journal=Mod. Pathol. |volume=17 |issue=3 |pages=316–27 |year=2004 |month=March |pmid=14976541 |doi=10.1038/modpathol.3800052 |url=}}</ref>
*[[Mucinous colorectal carcinoma]]: > 50% of the tumour.<ref name=pmid17679024 >{{cite journal |author=Tozawa E, Ajioka Y, Watanabe H, ''et al.'' |title=Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity? |journal=Pathol. Res. Pract. |volume=203 |issue=8 |pages=567–74 |year=2007 |pmid=17679024 |doi=10.1016/j.prp.2007.04.013 |url=}}</ref>
*[[Mucinous gastric carcinoma]]: > 50% of the tumour.
*Mucinous (noncystic) carcinoma of the [[pancreas]]: > 80% of the tumour.<ref name=pmid11145249>{{Cite journal  | last1 = Adsay | first1 = NV. | last2 = Pierson | first2 = C. | last3 = Sarkar | first3 = F. | last4 = Abrams | first4 = J. | last5 = Weaver | first5 = D. | last6 = Conlon | first6 = KC. | last7 = Brennan | first7 = MF. | last8 = Klimstra | first8 = DS. | title = Colloid (mucinous noncystic) carcinoma of the pancreas. | journal = Am J Surg Pathol | volume = 25 | issue = 1 | pages = 26-42 | month = Jan | year = 2001 | doi =  | PMID = 11145249 }}</ref>
*[[Mucinous breast carcinoma]]: > 90% of the tumour.<ref name=pmid22006768>{{Cite journal  | last1 = Dogan | first1 = E. | last2 = Aksoy | first2 = S. | last3 = Dizdar | first3 = O. | last4 = Arslan | first4 = C. | last5 = Dede | first5 = DS. | last6 = Ozisik | first6 = Y. | last7 = Altundag | first7 = K. | title = Pure mucinous carcinoma of the breast: a single center experience. | journal = J BUON | volume = 16 | issue = 3 | pages = 565-7 | month =  | year =  | doi =  | PMID = 22006768 }}</ref>
**One source suggests: > 50% of the tumour.<ref name=pmid20191033>{{cite journal |author=Park S, Koo J, Kim JH, Yang WI, Park BW, Lee KS |title=Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified |journal=J. Korean Med. Sci. |volume=25 |issue=3 |pages=361–8 |year=2010 |month=March |pmid=20191033 |pmc=2826751 |doi=10.3346/jkms.2010.25.3.361 |url=}}</ref>


====Images====
====Images====
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=====Case=====
=====Case=====
<gallery>
<gallery>
Image: Mucinous lung adenocarcinoma -- very low mag.jpg | MLA - very low mag.
Image: Mucinous lung adenocarcinoma -- very low mag.jpg | Mucinous [[lung adenocarcinoma]] (MLA) - very low mag.
Image: Mucinous lung adenocarcinoma -- low mag.jpg | MLA - low mag.
Image: Mucinous lung adenocarcinoma -- low mag.jpg | MLA - low mag.
Image: Mucinous lung adenocarcinoma -- intermed mag.jpg | MLA - intermed. mag.
Image: Mucinous lung adenocarcinoma -- intermed mag.jpg | MLA - intermed. mag.
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Image: Mucinous lung adenocarcinoma and airway - alt -- high mag.jpg | MLA - high mag.
Image: Mucinous lung adenocarcinoma and airway - alt -- high mag.jpg | MLA - high mag.
</gallery>
</gallery>
=====www=====
=====www=====
*[http://www.flickr.com/photos/pulmonary_pathology/3931951819/ Mucinous tumours of the ovary - several images (flickr.com)].
*[http://www.flickr.com/photos/pulmonary_pathology/3931951819/ Mucinous tumours of the ovary - several images (flickr.com)].
===Proportion of mucin===
The criteria for diagnosing "mucinous carcinoma" varies by the anatomical site:
*[[Mucinous prostate carcinoma]]: > 25% of the tumour.<ref name=pmid14976541>{{cite journal |author=Grignon DJ |title=Unusual subtypes of prostate cancer |journal=Mod. Pathol. |volume=17 |issue=3 |pages=316–27 |year=2004 |month=March |pmid=14976541 |doi=10.1038/modpathol.3800052 |url=}}</ref>
*[[Mucinous colorectal carcinoma]]: > 50% of the tumour.<ref name=pmid17679024 >{{cite journal |author=Tozawa E, Ajioka Y, Watanabe H, ''et al.'' |title=Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity? |journal=Pathol. Res. Pract. |volume=203 |issue=8 |pages=567–74 |year=2007 |pmid=17679024 |doi=10.1016/j.prp.2007.04.013 |url=}}</ref>
*[[Mucinous gastric carcinoma]]: > 50% of the tumour.
*Mucinous (noncystic) carcinoma of the [[pancreas]]: > 80% of the tumour.<ref name=pmid11145249>{{Cite journal  | last1 = Adsay | first1 = NV. | last2 = Pierson | first2 = C. | last3 = Sarkar | first3 = F. | last4 = Abrams | first4 = J. | last5 = Weaver | first5 = D. | last6 = Conlon | first6 = KC. | last7 = Brennan | first7 = MF. | last8 = Klimstra | first8 = DS. | title = Colloid (mucinous noncystic) carcinoma of the pancreas. | journal = Am J Surg Pathol | volume = 25 | issue = 1 | pages = 26-42 | month = Jan | year = 2001 | doi =  | PMID = 11145249 }}</ref>
*[[Mucinous breast carcinoma]]: > 90% of the tumour.<ref name=pmid22006768>{{Cite journal  | last1 = Dogan | first1 = E. | last2 = Aksoy | first2 = S. | last3 = Dizdar | first3 = O. | last4 = Arslan | first4 = C. | last5 = Dede | first5 = DS. | last6 = Ozisik | first6 = Y. | last7 = Altundag | first7 = K. | title = Pure mucinous carcinoma of the breast: a single center experience. | journal = J BUON | volume = 16 | issue = 3 | pages = 565-7 | month =  | year =  | doi =  | PMID = 22006768 }}</ref>
**One source suggests: > 50% of the tumour.<ref name=pmid20191033>{{cite journal |author=Park S, Koo J, Kim JH, Yang WI, Park BW, Lee KS |title=Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified |journal=J. Korean Med. Sci. |volume=25 |issue=3 |pages=361–8 |year=2010 |month=March |pmid=20191033 |pmc=2826751 |doi=10.3346/jkms.2010.25.3.361 |url=}}</ref>


==Molecular==
==Molecular==
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