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Difference between revisions of "Primitive neuroectodermal tumour"
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Primitive neuroectodermal tumour (view source)
Revision as of 13:44, 4 October 2017
, 13:44, 4 October 2017→CNS neuroblastoma: molecular cluster
Jensflorian (talk | contribs) (now abandoned) |
Jensflorian (talk | contribs) (→CNS neuroblastoma: molecular cluster) |
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===CNS neuroblastoma=== | ===CNS neuroblastoma=== | ||
* Since WHO 2016 CNS classification this is now a subgroup of [[Other CNS embryonal tumours]]. | |||
* Many CNS neuroblastoma / CNS ganglioneuroblastoma cluster molecularly into a group designated as CNS NB-FOXR2.<ref>{{Cite journal | last1 = Sturm | first1 = D. | last2 = Orr | first2 = BA. | last3 = Toprak | first3 = UH. | last4 = Hovestadt | first4 = V. | last5 = Jones | first5 = DTW. | last6 = Capper | first6 = D. | last7 = Sill | first7 = M. | last8 = Buchhalter | first8 = I. | last9 = Northcott | first9 = PA. | title = New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. | journal = Cell | volume = 164 | issue = 5 | pages = 1060-1072 | month = Feb | year = 2016 | doi = 10.1016/j.cell.2016.01.015 | PMID = 26919435 }}</ref> | |||
*Usu Olig-2 +ve. | |||
*Synaptophysin +ve. | |||
===CNS ganglioneuroblastoma=== | ===CNS ganglioneuroblastoma=== | ||
* This is now a subgroup of [[Other CNS embryonal tumours]]. | |||
===Lipomatous medulloblastoma=== | ===Lipomatous medulloblastoma=== | ||
* These tumors are now designated as [[Cerebellar liponeurocytoma]]. | |||
===Melanotic medulloblastoma=== | |||
* In WHO CNS 1997 still a distinct tumor. | |||
* These tumors are now considered a variant of [[medulloblastoma]]. | |||
===Medullomyoblastoma=== | ===Medullomyoblastoma=== | ||
* Embryonal tumor with primitive neuronal cells and striated muscle component. | |||
* First description in 1933.<ref>{{Cite journal | last1 = Brody | first1 = BS. | last2 = German | first2 = WJ. | title = Medulloblastoma of the Cerebellum: A Report of 15 Cases. | journal = Yale J Biol Med | volume = 6 | issue = 1 | pages = 19-29 | month = Oct | year = 1933 | doi = | PMID = 21433586 }}</ref> | |||
* Since WHO 2007 CNS tumor classification tumors were classified as ''medulloblastoma with myogenic differentiation''. | |||
===Medulloepithelioma=== | ===Medulloepithelioma=== | ||