98
edits
Difference between revisions of "Squamous cell carcinoma of the uterine cervix"
Jump to navigation
Jump to search
Squamous cell carcinoma of the uterine cervix (view source)
Revision as of 13:58, 15 August 2017
, 13:58, 15 August 2017→IHC
(→IHC) |
|||
| (4 intermediate revisions by one other user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Cervical squamous cell carcinoma in situ.jpg | |||
| Width = | |||
| Caption = Cervical squamous cell carcinoma in situ. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[squamous metaplasia of the uterine cervix]], [[high-grade squamous intraepithelial lesion]] | |||
| Stains = | |||
| IHC = p16 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = white lesion ~ usu. close to transformation zone | |||
| Grossing = | |||
| Site = [[uterine cervix]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = most common cervical malignancy | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usu. good, dependent on stage | |||
| Other = | |||
| ClinDDx = | |||
| Tx = cervical cone, radical hysterectomy | |||
}} | |||
'''Squamous cell carcinoma of the uterine cervix''', also '''cervical squamous cell carcinoma''', is the most common primary malignancy of the [[uterine cervix]]. | '''Squamous cell carcinoma of the uterine cervix''', also '''cervical squamous cell carcinoma''', is the most common primary malignancy of the [[uterine cervix]]. | ||
| Line 30: | Line 61: | ||
*Nuclear atypia. | *Nuclear atypia. | ||
SCC of the cervix versus | SCC of the cervix versus [[high-grade squamous intraepithelial lesion]] (carcinoma in situ): | ||
Invasive cancer look for: | Invasive cancer look for: | ||
*Eosinophilia. | *Eosinophilia. | ||
| Line 45: | Line 76: | ||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: | Image:Cervical squamous cell carcinoma in situ.jpg|SCC in situ. (WC) | ||
</gallery> | </gallery> | ||
www: | www: | ||
| Line 80: | Line 111: | ||
==IHC== | ==IHC== | ||
*CK7, p63, p16 +ve (except verrucous variant) | |||
*Factor VIII - to look for [[LVI]]. | *Factor VIII - to look for [[LVI]]. | ||
==Sign out== | ==Sign out== | ||
===Biopsy=== | |||
Early invasive SCC - things to report: | Early invasive SCC - things to report: | ||
*Depth of invasion. | *Depth of invasion. | ||
*Length of tumour. | *Length of tumour. | ||
*Number of blocks with tumour. | *Number of blocks with tumour. | ||
*LVI. | *[[Lymphovascular invasion]] (LVI). | ||
*Margins. | *Margins. | ||
| Line 95: | Line 128: | ||
-- DEPTH OF INVASION AND LENTH OF TUMOUR CANNOT BE ASSESSED. | -- DEPTH OF INVASION AND LENTH OF TUMOUR CANNOT BE ASSESSED. | ||
-- LYMPHOVASCULAR INVASION NOT APPARENT. | -- LYMPHOVASCULAR INVASION NOT APPARENT. | ||
</pre> | |||
<pre> | |||
LESION, UTERINE CERVIX, BIOPSY: | |||
- INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, FRAGMENTED. | |||
- PLEASE SEE TUMOUR SUMMARY. | |||
TUMOUR SUMMARY - UTERINE CERVIX | |||
Specimen: Cervix. | |||
Procedure: Biopsy. | |||
Tumour Site: Cannot be determined. | |||
Tumour Size: Cannot be determined - see comment. | |||
Histologic Type: Squamous cell carcinoma, keratinizing. | |||
Histologic Grade: G2: Moderately differentiated. | |||
Stromal Invasion: Extent cannot be assessed - see comment. | |||
Lymph-Vascular Invasion: Not identified. | |||
Comment: | |||
The tissue submitted is essentially all tumour. The largest fragment measures 1.2 x 1.4 cm | |||
in the plane of section. Fragmentation and lack of normal histology preclude orientation. | |||
As both the in plane dimensions exceed 0.7 cm, this is at least a pT1b. | |||
</pre> | |||
===TAH-BSO=== | |||
<pre> | |||
UTERUS, CERVIX, RIGHT AND LEFT OVARIES AND BILATERAL UTERINE TUBES, TOTAL HYSTERECTOMY AND | |||
BILATERAL SALPINGO-OOPHORECTOMY: | |||
- INVASIVE SQUAMOUS CELL CARCINOMA, pT1a1, pNx. | |||
-- MARGINS NEGATIVE FOR MALIGNANCY. | |||
-- PLEASE SEE TUMOUR SUMMARY. | |||
- PROLIFERATIVE ENDOMETRIUM. | |||
- UTERINE LEIOMYOMAS. | |||
- UTERINE TUBES WITH CHANGES COMPATIBLE WITH LIGATION, NO SIGNIFICANT PATHOLOGY. | |||
- OVARIES WITHOUT SIGNIFICANT PATHOLOGY. | |||
</pre> | </pre> | ||