Difference between revisions of "High-grade prostatic intraepithelial neoplasia-like ductal adenocarcinoma of the prostate"
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'''High-grade prostatic intraepithelial neoplasia-like ductal adenocarcinoma of the prostate''', abbreviated '''PIN-like adenocarcinoma''', is an uncommon type of [[prostate cancer]] that histomorphologically mimics [[ | '''High-grade prostatic intraepithelial neoplasia-like ductal adenocarcinoma of the prostate''', abbreviated '''PIN-like adenocarcinoma''', is an uncommon type of [[prostate cancer]] that histomorphologically mimics [[high-grade prostatic intraepithelial neoplasia]] (HGPIN). | ||
==General== | ==General== | ||
| Line 6: | Line 6: | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid16607376>{{Cite journal | last1 = Hameed | first1 = O. | last2 = Humphrey | first2 = PA. | title = Stratified epithelium in prostatic adenocarcinoma: a mimic of high-grade prostatic intraepithelial neoplasia. | journal = Mod Pathol | volume = 19 | issue = 7 | pages = 899-906 | month = Jul | year = 2006 | doi = 10.1038/modpathol.3800601 | PMID = 16607376 }}</ref> | Features:<ref name=pmid16607376>{{Cite journal | last1 = Hameed | first1 = O. | last2 = Humphrey | first2 = PA. | title = Stratified epithelium in prostatic adenocarcinoma: a mimic of high-grade prostatic intraepithelial neoplasia. | journal = Mod Pathol | volume = 19 | issue = 7 | pages = 899-906 | month = Jul | year = 2006 | doi = 10.1038/modpathol.3800601 | PMID = 16607376 }}</ref><ref name=pmid18496142>{{Cite journal | last1 = Tavora | first1 = F. | last2 = Epstein | first2 = JI. | title = High-grade prostatic intraepithelial neoplasialike ductal adenocarcinoma of the prostate: a clinicopathologic study of 28 cases. | journal = Am J Surg Pathol | volume = 32 | issue = 7 | pages = 1060-7 | month = Jul | year = 2008 | doi = 10.1097/PAS.0b013e318160edaf | PMID = 18496142 }}</ref> | ||
* | *Columnar cells with pseudostratified nuclei. | ||
**Non-columnar cells with round nuclei also described. | |||
*Simple glands: flat, tufted or micropapillary. | |||
Note: | Note: | ||
*Vaguely similar to a tubular adenoma of the colon. | *Vaguely similar to a [[tubular adenoma of the colon]]. | ||
DDx: | DDx: | ||
*[[HGPIN]]. | *[[HGPIN]] - has basal cells or a few glands. | ||
*[[Ductal adenocarcinoma of the prostate]] - papillary architecture. | |||
===Image=== | ===Image=== | ||
| Line 25: | Line 28: | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Prostate | [[Category:Prostate carcinoma]] | ||
Latest revision as of 03:16, 6 March 2017
High-grade prostatic intraepithelial neoplasia-like ductal adenocarcinoma of the prostate, abbreviated PIN-like adenocarcinoma, is an uncommon type of prostate cancer that histomorphologically mimics high-grade prostatic intraepithelial neoplasia (HGPIN).
General
- Described in ~2006.[1][2]
- May be confused with prostatic intraepithelial neoplasia (PIN).[3]
Microscopic
- Columnar cells with pseudostratified nuclei.
- Non-columnar cells with round nuclei also described.
- Simple glands: flat, tufted or micropapillary.
Note:
- Vaguely similar to a tubular adenoma of the colon.
DDx:
- HGPIN - has basal cells or a few glands.
- Ductal adenocarcinoma of the prostate - papillary architecture.
Image
See also
References
- ↑ 1.0 1.1 Hameed, O.; Humphrey, PA. (Jul 2006). "Stratified epithelium in prostatic adenocarcinoma: a mimic of high-grade prostatic intraepithelial neoplasia.". Mod Pathol 19 (7): 899-906. doi:10.1038/modpathol.3800601. PMID 16607376.
- ↑ Lee, TK.; Miller, JS.; Epstein, JI. (Jun 2010). "Rare histological patterns of prostatic ductal adenocarcinoma.". Pathology 42 (4): 319-24. doi:10.3109/00313021003767314. PMID 20438402.
- ↑ 3.0 3.1 Tavora, F.; Epstein, JI. (Jul 2008). "High-grade prostatic intraepithelial neoplasialike ductal adenocarcinoma of the prostate: a clinicopathologic study of 28 cases.". Am J Surg Pathol 32 (7): 1060-7. doi:10.1097/PAS.0b013e318160edaf. PMID 18496142.