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Difference between revisions of "Keloid"
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→Microscopic
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| Micro = thick collagen bundles - surrounded by paler staining fibroblasts, loss of adnexal structures | | Micro = thick collagen bundles - surrounded by paler staining fibroblasts, loss of adnexal structures | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = hypertrophic scar | | LMDDx = hypertrophic scar, keloidal [[dermatofibroma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = typically dark skinned individuals | | Clinicalhx = typically dark skinned individuals, prior trauma, burn or surgery | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
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| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = intralesional steroid, radiotherapy, surgery | |||
}} | }} | ||
{{ Infobox external links | {{ Infobox external links | ||
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}} | }} | ||
:''Hypertrophic scar'' redirects here. | :''Hypertrophic scar'' redirects here. | ||
'''Keloid''' is an uncommon abnormal [[scar|scarring]]. | '''Keloid''' is an uncommon abnormal [[scar|scarring]] of the [[skin]] that extends beyond the boundaries of the initial injury. | ||
==General== | ==General== | ||
*Sites of previous trauma/surgery, | *Sites of previous trauma/surgery/burn, especially in dark skinned individuals.<ref name=Ref_WMSP492>{{Ref WMSP|492}}</ref> | ||
*Various treatments. | *Various treatments: | ||
**Injections: corticosteroid such as triamcinolone acetonide (''Kenalog'').<ref name=pmid25396172>{{Cite journal | last1 = Trisliana Perdanasari | first1 = A. | last2 = Lazzeri | first2 = D. | last3 = Su | first3 = W. | last4 = Xi | first4 = W. | last5 = Zheng | first5 = Z. | last6 = Ke | first6 = L. | last7 = Min | first7 = P. | last8 = Feng | first8 = S. | last9 = Zhang | first9 = YX. | title = Recent developments in the use of intralesional injections keloid treatment. | journal = Arch Plast Surg | volume = 41 | issue = 6 | pages = 620-9 | month = Nov | year = 2014 | doi = 10.5999/aps.2014.41.6.620 | PMID = 25396172 }}</ref> | **Surgery. | ||
**Radiotherapy. | |||
**Injections: corticosteroid such as triamcinolone acetonide (''Kenalog'').<ref name=pmid26758090>{{Cite journal | last1 = Acosta | first1 = S. | last2 = Ureta | first2 = E. | last3 = Yañez | first3 = R. | last4 = Oliva | first4 = N. | last5 = Searle | first5 = S. | last6 = Guerra | first6 = C. | title = Effectiveness of Intralesional Triamcinolone in the Treatment of Keloids in Children. | journal = Pediatr Dermatol | volume = 33 | issue = 1 | pages = 75-9 | month = Jan | year = 2016 | doi = 10.1111/pde.12746 | PMID = 26758090 }}</ref><ref name=pmid25396172>{{Cite journal | last1 = Trisliana Perdanasari | first1 = A. | last2 = Lazzeri | first2 = D. | last3 = Su | first3 = W. | last4 = Xi | first4 = W. | last5 = Zheng | first5 = Z. | last6 = Ke | first6 = L. | last7 = Min | first7 = P. | last8 = Feng | first8 = S. | last9 = Zhang | first9 = YX. | title = Recent developments in the use of intralesional injections keloid treatment. | journal = Arch Plast Surg | volume = 41 | issue = 6 | pages = 620-9 | month = Nov | year = 2014 | doi = 10.5999/aps.2014.41.6.620 | PMID = 25396172 }}</ref> | |||
Note: | Note: | ||
*Reported as "keloidal-type collagen"; the clinician decides between ''hypertrophic scar'' and ''keloid''. | *Reported as "keloidal-type collagen"; the clinician decides between ''hypertrophic scar'' and ''keloid''. | ||
**A keloid grows beyond the boundaries of the injury site,<ref name=pmid19608056>{{Cite journal | last1 = Kelly | first1 = AP. | title = Update on the management of keloids. | journal = Semin Cutan Med Surg | volume = 28 | issue = 2 | pages = 71-6 | month = Jun | year = 2009 | doi = 10.1016/j.sder.2009.04.002 | PMID = 19608056 }}</ref> a hypertrophic scar does not. | |||
==Gross== | ==Gross== | ||
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DDx: | DDx: | ||
*Hypertrophic scar.<ref name=pmid20927486>{{Cite journal | last1 = Gauglitz | first1 = GG. | last2 = Korting | first2 = HC. | last3 = Pavicic | first3 = T. | last4 = Ruzicka | first4 = T. | last5 = Jeschke | first5 = MG. | title = Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. | journal = Mol Med | volume = 17 | issue = 1-2 | pages = 113-25 | month = | year = | doi = 10.2119/molmed.2009.00153 | PMID = 20927486 | PMC = 3022978 }}</ref> | *Hypertrophic scar.<ref name=pmid20927486>{{Cite journal | last1 = Gauglitz | first1 = GG. | last2 = Korting | first2 = HC. | last3 = Pavicic | first3 = T. | last4 = Ruzicka | first4 = T. | last5 = Jeschke | first5 = MG. | title = Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. | journal = Mol Med | volume = 17 | issue = 1-2 | pages = 113-25 | month = | year = | doi = 10.2119/molmed.2009.00153 | PMID = 20927486 | PMC = 3022978 }}</ref> | ||
*[[Dermatofibroma]] - esp. ''keloidal dermatofibroma''.<ref name=pmid9591726>{{Cite journal | last1 = Kuo | first1 = TT. | last2 = Hu | first2 = S. | last3 = Chan | first3 = HL. | title = Keloidal dermatofibroma: report of 10 cases of a new variant. | journal = Am J Surg Pathol | volume = 22 | issue = 5 | pages = 564-8 | month = May | year = 1998 | doi = | PMID = 9591726 }}</ref> | |||
===Images=== | ===Images=== | ||