Endocervical adenocarcinoma in situ: Difference between revisions

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#*Normal gland spacing - lack of complexity ("lobular pattern").  
#*Normal gland spacing - lack of complexity ("lobular pattern").  
#*Normal gland depth (subjective).
#*Normal gland depth (subjective).
Ioffe, et al, :<ref name=pmid12657929>{{cite journal |author=Ioffe OB, Sagae S, Moritani S, Dahmoush L, Chen TT, Silverberg SG. |title=Proposal of a new scoring scheme for the diagnosis of noninvasive endocervical glandular lesions |journal=Am J Surg Pathol | volume=27 | issue=4| pages=452–460 | year=2003 | pmid=12657929 |pmc= |doi= |url= }}</ref> devised a reproducible schema by which one might discern reactive glandular atypia, glandular dysplasia, and adenocarcinoma in situ, summarized in the table below from the article:
Sum the scores for stratification, nuclear atypia, and mitoses/apoptotic bodies<br>
<br>
Stratification<br>
None (0 points)<br>
Mild (1 point)<br>
Moderate (2 points)<br>
Up to the luminal surface (3 points)<br>
<br>
Nuclear atypia<br>
As normal (0 points)<br>
Small (size of normal) or slightly enlarged uniform nuclei, minimal hyperchromasia, little dispolarity, no nucleoli (1 point)<br>
Nuclear enlargement (≤3× normal), moderate anisocytosis/hyperchromasia/dispolarity, occasional small nucleoli (2 points)<br>
Large nuclei (>3× normal), marked anisocytosis, marked hyperchromasia, severe dispolarity, frequent prominent nucleoli (3 points)<br>
<br>
Mitoses and apoptoses in two most active glands, number per gland (average between two glands)<br>
None (0 points)<br>
Less than 0.5 per gland (1 point)<br>
0.6–3.0 per gland (2 points)<br>
>3.0 per gland (3 points)<br>
<br>
Total score 0–3 = benign 4–5 = endocervical glandular dysplasia (EGD) 6–9 = adenocarcinoma in situ


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===Images===
===Images===
====Case - ECC====
<gallery>
<gallery>
Image: Endocervical adenocarcinoma in situ -- intermed mag.jpg | AIS - intermed. mag.
Image: Endocervical adenocarcinoma in situ -- intermed mag.jpg | AIS - intermed. mag.
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Image: Endocervical adenocarcinoma in situ 2a -- very high mag.jpg | AIS - very high mag.
Image: Endocervical adenocarcinoma in situ 2a -- very high mag.jpg | AIS - very high mag.
Image: Endocervical adenocarcinoma in situ 2b -- very high mag.jpg | AIS - very high mag.
Image: Endocervical adenocarcinoma in situ 2b -- very high mag.jpg | AIS - very high mag.
</gallery>
====Case - biopsy====
<gallery>
Image: Endocervical adenocarcinoma in situ --- intermed mag.jpg | AIS - intermed. mag.
Image: Endocervical adenocarcinoma in situ --- high mag.jpg | AIS - high mag.
Image: Endocervical adenocarcinoma in situ --- very high mag.jpg | AIS - very high mag.
Image: Endocervical adenocarcinoma in situ - alt --- intermed mag.jpg | AIS - intermed. mag.
Image: Endocervical adenocarcinoma in situ - alt --- high mag.jpg | AIS - high mag.
Image: Endocervical adenocarcinoma in situ - alt --- very high mag.jpg | AIS - very high mag.
Image: Endocervical adenocarcinoma in situ - p16 --- intermed mag.jpg | AIS - p16 - intermed. mag.
Image: Endocervical adenocarcinoma in situ - p16 --- high mag.jpg | AIS - p16 - high mag.
Image: Endocervical adenocarcinoma in situ - p16 --- very high mag.jpg | AIS - p16 - very high mag.
Image: Endocervical adenocarcinoma in situ - ki67 --- intermed mag.jpg | AIS - Ki-67 - intermed. mag.
Image: Endocervical adenocarcinoma in situ - ki67 --- high mag.jpg | AIS - Ki-67 - high mag.
Image: Endocervical adenocarcinoma in situ - ki67 --- very high mag.jpg | AIS - Ki-67 - very high mag.
</gallery>
</gallery>
====www====
====www====
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