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Difference between revisions of "Cardiomyopathy"
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==Dilated cardiomyopathy== | ==Dilated cardiomyopathy== | ||
*Abbreviated ''DCM''. | |||
===General=== | ===General=== | ||
*Most common of the cardiomyopathies. | *Most common of the cardiomyopathies. | ||
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*Myocarditis - leading cause, usually viral.<ref name=pmid19017683>{{cite journal |author=Luk A, Ahn E, Soor GS, Butany J |title=Dilated cardiomyopathy: a review |journal=J. Clin. Pathol. |volume=62 |issue=3 |pages=219–25 |year=2009 |month=March |pmid=19017683 |doi=10.1136/jcp.2008.060731 |url=}}</ref> | *Myocarditis - leading cause, usually viral.<ref name=pmid19017683>{{cite journal |author=Luk A, Ahn E, Soor GS, Butany J |title=Dilated cardiomyopathy: a review |journal=J. Clin. Pathol. |volume=62 |issue=3 |pages=219–25 |year=2009 |month=March |pmid=19017683 |doi=10.1136/jcp.2008.060731 |url=}}</ref> | ||
*Familial ~ 30% - can be AD with variable penetrance, AR, X-linked. | *Familial ~ 30% - can be AD with variable penetrance, AR, X-linked. | ||
*In the [[forensic pathology|forensic]] context, usually caused by alcoholism.<ref name=Ref_HoFP43>{{Ref HoFP|43}}</ref> | *In the [[forensic pathology|forensic]] context, usually caused by [[alcoholism]].<ref name=Ref_HoFP43>{{Ref HoFP|43}}</ref> | ||
===Microscopic=== | ===Microscopic=== | ||
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===Gross=== | ===Gross=== | ||
Features:<ref name=emedicine1612324>URL: [http://emedicine.medscape.com/article/1612324-overview http://emedicine.medscape.com/article/1612324-overview].</ref> | Features:<ref name=emedicine1612324>URL: [http://emedicine.medscape.com/article/1612324-overview http://emedicine.medscape.com/article/1612324-overview].</ref> | ||
* | *Right ventricular wall thinning/replacement with fat. † | ||
**Especially fat where fat is ''not'' usually seen - posterior RV wall, RVOT. | **Especially fat where fat is ''not'' usually seen - posterior RV wall, RVOT. | ||
*Septum usually has relative sparing | *Septum usually has relative sparing | ||
**Thus, endomyocardial biopsy is ''not'' reliable. | **Thus, endomyocardial biopsy is ''not'' reliable. | ||
*+/-Aneurysms/dilation. | *+/-Aneurysms/dilation. | ||
Note: | |||
*† May involve the left ventricle.<ref name=pmid23761986>{{cite journal |author=Romero J, Mejia-Lopez E, Manrique C, Lucariello R |title=Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC/D): A Systematic Literature Review |journal=Clin Med Insights Cardiol |volume=7 |issue= |pages=97–114 |year=2013 |pmid=23761986 |pmc=3667685 |doi=10.4137/CMC.S10940 |url=}}</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
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*Myocytes have "bubbly" appearance with loss of myofibres and cross-striations. | *Myocytes have "bubbly" appearance with loss of myofibres and cross-striations. | ||
Images | ====Images==== | ||
<gallery> | |||
Image: Arrhythmogenic right ventricular cardiomyopathy - histology.jpg | ARVC. (WC) | |||
</gallery> | |||
=====www===== | |||
*[http://path.upmc.edu/cases/case223.html ARVC - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case223.html ARVC - several images (upmc.edu)]. | ||