Atypical lobular hyperplasia: Difference between revisions
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'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the breast characterized cellular proliferation and cellular dyscohesion. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Atypical lobular hyperplasia -- high mag.jpg | |||
| Width = | |||
| Caption = Atypical lobular hyperplasia. [[H&E stain]]. (WC/Nephron) | |||
| Synonyms = | |||
| Micro = morphologic changes ('''a'''typia minimal - usually, '''b'''orders of cells distinct/visible - ''dyscohesive'', '''c'''lear cytoplasm (focal), '''d'''istend duct, '''e'''ccentric nucleus, usu. round, '''f'''illed ducts ('''no''' luminal spaces - '''key feature'''), limited extent (<50% of terminal duct lobular unit is involved) | |||
| Subtypes = | |||
| LMDDx = [[lobular carcinoma in situ]], [[lobular carcinoma]] | |||
| Stains = | |||
| IHC = E-cadherin -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[breast]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the [[breast]] characterized by cellular proliferation and cellular dyscohesion. | |||
It can be seen as the | It can be seen as the precursor to [[lobular carcinoma in situ]], the precursor of [[lobular carcinoma]]. | ||
==General== | ==General== | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* | #Morphologic changes - memory device ''ABCDEF'': | ||
#*'''A'''typia minimal - usually. | |||
#**Relatively small ~1-2x size lymphocyte. | |||
#*'''B'''orders of cells distinct/visible - ''dyscohesive''. | |||
#*'''C'''lear cytoplasm (focal). | |||
#**May have a signet ring cell-like appearance. | |||
#*'''D'''istend duct. | |||
#*'''E'''ccentric nucleus, usu. round. | |||
#*'''F'''illed ducts. | |||
#**'''No''' luminal spaces - '''key feature'''. | |||
#***Partially filled ducts are ''not'' LCIS. | |||
#Limited extent: <50% of terminal duct lobular unit (TDLU) is involved. | |||
DDx: | DDx: | ||
*[[Lobular carcinoma in situ]]. | *[[Lobular carcinoma in situ]]. | ||
*[[Lobular carcinoma]]. | *[[Lobular carcinoma]]. | ||
===Images=== | |||
<gallery> | |||
Image: Atypical lobular hyperplasia -- low mag.jpg | ALH - low mag. (WC) | |||
Image: Atypical lobular hyperplasia -- intermed mag.jpg | ALH - intermed. mag. (WC) | |||
Image: Atypical lobular hyperplasia -- high mag.jpg | ALH - high mag. (WC) | |||
Image: Atypical lobular hyperplasia - E-cadherin -- intermed mag.jpg | ALH - E-cadherin - intermed. mag. (WC) | |||
Image: Atypical lobular hyperplasia - E-cadherin -- high mag.jpg | ALH - E-cadherin - high mag. (WC) | |||
</gallery> | |||
<gallery> | |||
Image: Benign breast - E-cadherin -- intermed mag.jpg | Benign breast - E-cadherin - intermed. mag. (WC) | |||
Image: Benign breast - E-cadherin -- high mag.jpg | Benign breast - E-cadherin - high mag. (WC) | |||
Image: Benign breast - E-cadherin - alt -- high mag.jpg | Benign breast - E-cadherin - high mag. (WC) | |||
</gallery> | |||
==IHC== | ==IHC== | ||