Difference between revisions of "Endometrium with changes due to selective progesterone receptor modulators"
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'''Selective progesterone receptor modulators''', abbreviated '''SPRMs''', are a class of drugs that block the action of progesterone. They are used to treat [[uterine fibroids]].<ref name=pmid23018219>{{Cite journal | last1 = Williams | first1 = AR. | last2 = Bergeron | first2 = C. | last3 = Barlow | first3 = DH. | last4 = Ferenczy | first4 = A. | title = Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate. | journal = Int J Gynecol Pathol | volume = 31 | issue = 6 | pages = 556-69 | month = Nov | year = 2012 | doi = 10.1097/PGP.0b013e318251035b | PMID = 23018219 }}</ref> | '''Selective progesterone receptor modulators''', abbreviated '''SPRMs''', are a class of drugs that block the action of progesterone. They are used to treat [[uterine fibroids]].<ref name=pmid23018219>{{Cite journal | last1 = Williams | first1 = AR. | last2 = Bergeron | first2 = C. | last3 = Barlow | first3 = DH. | last4 = Ferenczy | first4 = A. | title = Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate. | journal = Int J Gynecol Pathol | volume = 31 | issue = 6 | pages = 556-69 | month = Nov | year = 2012 | doi = 10.1097/PGP.0b013e318251035b | PMID = 23018219 }}</ref> | ||
==Microscopic== | |||
Features:<ref name=pmid23018219/> | |||
*Glandular changes - extensive cystic dilatation. | |||
*Inactive appearing glandular epithelium or abortive subnuclear vacuolization. | |||
*Rare mitoses and apoptosis. | |||
*Abnormal stromal vessels - common. | |||
DDx: | |||
*[[Simple endometrial hyperplasia]]. | |||
==See also== | ==See also== |
Revision as of 18:38, 3 January 2017
Selective progesterone receptor modulators, abbreviated SPRMs, are a class of drugs that block the action of progesterone. They are used to treat uterine fibroids.[1]
Microscopic
Features:[1]
- Glandular changes - extensive cystic dilatation.
- Inactive appearing glandular epithelium or abortive subnuclear vacuolization.
- Rare mitoses and apoptosis.
- Abnormal stromal vessels - common.
DDx: