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Epidermal inclusion cyst (view source)
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'''Epidermal inclusion cyst''', abbreviated '''EIC''', is a very common [[skin | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Epidermal_inclusion_cyst_--_high_mag.jpg | |||
| Width = | |||
| Caption = Epidermal inclusion cyst. [[H&E stain]]. | |||
| Micro = cyst lining by a stratified squamous epithelium with a granular layer - contains keratin; no significant nuclear atypia; +/-[[granuloma|granulomatous inflammation]] (due to rupture) | |||
| Subtypes = | |||
| LMDDx = [[pilar cyst]], [[eccrine hidrocystoma]] (eyelid), [[dermoid cyst]], cystic [[squamous cell carcinoma of the skin|squamous cell carcinoma]], [[keratoacanthoma]], [[dermatofibrosarcoma protuberans]], hybrid epidermoid and trichilemmal cyst | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = nodule +/-yellow colour | |||
| Grossing = | |||
| Site = [[skin]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other [[skin cysts]], [[gouty tophus]] | |||
}} | |||
'''Epidermal inclusion cyst''', abbreviated '''EIC''', is a very common [[skin]] pathology. It is also know as '''epidermal cyst''', '''epidermoid cyst''',<ref name=Ref_Derm302>{{Ref Derm|302}}</ref> and '''follicular cyst, infundibular type'''. | |||
''Testicular epidermoid cyst'' is dealt with separately in ''[[epidermoid cyst of the testis]]''. | |||
==General== | ==General== | ||
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*[[Pilar cyst]] - indistinguishable on gross.<ref name=dermis36946>URL: [http://www.dermis.net/dermisroot/en/36946/diagnose.htm http://www.dermis.net/dermisroot/en/36946/diagnose.htm]. Accessed on: 2 November 2012.</ref> | *[[Pilar cyst]] - indistinguishable on gross.<ref name=dermis36946>URL: [http://www.dermis.net/dermisroot/en/36946/diagnose.htm http://www.dermis.net/dermisroot/en/36946/diagnose.htm]. Accessed on: 2 November 2012.</ref> | ||
*[[Melanoma]].<ref name=pmid18201468/> | *[[Melanoma]].<ref name=pmid18201468/> | ||
*[[Gouty tophus]]. | |||
===Image=== | ===Image=== | ||
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Image:Inflamed_epidermal_inclusion_cyst.jpg |Epidermal inclusion cyst. (WC) | Image:Inflamed_epidermal_inclusion_cyst.jpg |Epidermal inclusion cyst. (WC) | ||
</gallery> | </gallery> | ||
==Microscopic== | |||
Features: | Features: | ||
*Cyst lining | *Cyst lining by a stratified squamous epithelium with a granular layer - '''key feature'''.<ref>URL: [http://emedicine.medscape.com/article/1058907-diagnosis http://emedicine.medscape.com/article/1058907-diagnosis]. Accessed on: 18 March 2011.</ref> | ||
* | **No significant nuclear atypia. | ||
* | **Contains keratin - acellular, lamellar appearance. | ||
*+/-[[granuloma|Granulomatous inflammation]] due to rupture. | *+/-[[granuloma|Granulomatous inflammation]] due to rupture. | ||
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===Images=== | ===Images=== | ||
<gallery> | |||
Image: Epidermal inclusion cyst -- intermed mag.jpg | EIC - intermed. mag. (WC) | |||
Image: Epidermal inclusion cyst -- high mag.jpg | EIC - high mag. (WC) | |||
Image: Epidermal inclusion cyst -- very high mag.jpg | EIC - very high mag. (WC) | |||
</gallery> | |||
<gallery> | |||
Image:Dermoid cyst intracranial.jpg | Dermoid cyst - intracranial. (WC) | |||
</gallery> | |||
www: | www: | ||
*[http://www.flickr.com/photos/euthman/5517587941/in/photostream/ Epidermal inclusion cyst (flickr.com)]. | *[http://www.flickr.com/photos/euthman/5517587941/in/photostream/ Epidermal inclusion cyst (flickr.com)]. | ||
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===Ruptured=== | ===Ruptured=== | ||
<pre> | |||
Lesion, Left Elbow, Excision: | |||
- Benign epidermal inclusion cyst with evidence of rupture. | |||
</pre> | |||
====Block letters==== | |||
<pre> | <pre> | ||
SKIN LESION, RIGHT CHEEK, EXCISION: | SKIN LESION, RIGHT CHEEK, EXCISION: | ||
- RUPTURED EPIDERMAL INCLUSION CYST. | - RUPTURED EPIDERMAL INCLUSION CYST. | ||
</pre> | |||
===Overlying skin=== | |||
<pre> | |||
SKIN LESION (QUERY CYST), RIGHT JAW, EXCISION: | |||
- EPIDERMAL INCLUSION CYST. | |||
- BENIGN (OVERLYING) SKIN WITH SOLAR ELASTOSIS. | |||
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. | |||
</pre> | |||
===Not quite a cyst=== | |||
<pre> | |||
"CYST", LEFT INDEX FINGER, EXCISION: | |||
- LARGE (CYST-LIKE) EPIDERMAL INVAGINATION CONTAINING KERATIN. | |||
- DERMAL SCAR. | |||
- MINIMAL (NONSPECIFIC) PERIVASCULAR INFLAMMATION. | |||
- NO DEFINITE CYST APPARENT. | |||
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. | |||
</pre> | </pre> | ||
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==See also== | ==See also== | ||
[[Dermal cysts]]. | *[[Dermal cysts]]. | ||
*[[Epidermoid cyst of the testis]]. | |||
*[[Cholesteatoma]]. | |||
==References== | ==References== | ||