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Difference between revisions of "Paneth cell"
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→Paneth cell metaplasia
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[[Image: Paneth cell metaplasia in the left colon -- extremely high mag.jpg | thumb | right |Paneth cell metaplasia. [[H&E stain]].]] | [[Image: Paneth cell metaplasia in the left colon -- extremely high mag.jpg | thumb | right |Paneth cell metaplasia and lamina propria [[eosinophil]]s. [[H&E stain]]. ]] | ||
The '''Paneth cell''' is characteristic of the [[small intestine]]. It is also normal in the [[cecum]], ascending colon and transverse colon. | The '''Paneth cell''' is characteristic of the [[small intestine]]. It is also normal in the [[cecum]], ascending colon and transverse colon. | ||
'''Paneth cell metaplasia''' | '''Paneth cell metaplasia''', abbreviated '''PCM''', redirects to this article. | ||
==General== | ==General== | ||
*Paneth cells should ''not'' be in the left colon<ref name=pmid11851832>{{cite journal |author=Tanaka M, Saito H, Kusumi T, ''et al'' |title=Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease |journal=J. Gastroenterol. Hepatol. |volume=16 |issue=12 |pages=1353–9 |year=2001 |month=December |pmid=11851832 |doi= |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2001&volume=16&issue=12&spage=1353}}</ref> | *Paneth cells should ''not'' be in the left colon.<ref name=pmid11851832>{{cite journal |author=Tanaka M, Saito H, Kusumi T, ''et al'' |title=Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease |journal=J. Gastroenterol. Hepatol. |volume=16 |issue=12 |pages=1353–9 |year=2001 |month=December |pmid=11851832 |doi= |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2001&volume=16&issue=12&spage=1353}}</ref> | ||
* | **If you see 'em there it is '''Paneth cell metaplasia'''. | ||
===Paneth cell metaplasia=== | |||
If PCM is present: | |||
*Think of [[inflammatory bowel disease]] and other long-standing injurious processes. | |||
*PCM in the context of colorectal adenomas may be associated with a higher risk of colorectal neoplasia.<ref name=pmid23232853>{{Cite journal | last1 = Pai | first1 = RK. | last2 = Rybicki | first2 = LA. | last3 = Goldblum | first3 = JR. | last4 = Shen | first4 = B. | last5 = Xiao | first5 = SY. | last6 = Liu | first6 = X. | title = Paneth cells in colonic adenomas: association with male sex and adenoma burden. | journal = Am J Surg Pathol | volume = 37 | issue = 1 | pages = 98-103 | month = Jan | year = 2013 | doi = 10.1097/PAS.0b013e318267b02e | PMID = 23232853 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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*Intraepithelial [[eosinophil]]s. | *Intraepithelial [[eosinophil]]s. | ||
**Eosinophils have smaller (~1/2) more intensely red granules. | **Eosinophils have smaller (~1/2) more intensely red granules. | ||
===Images=== | |||
<gallery> | |||
Image: Paneth cell metaplasia in the left colon -- intermed mag.jpg | PCM - intermed. mag. (WC) | |||
Image: Paneth cell metaplasia in the left colon -- high mag.jpg | PCM - high mag. (WC) | |||
Image: Paneth cell metaplasia in the left colon -- very high mag.jpg | PCM - very high mag. (WC) | |||
Image: Paneth cell metaplasia in the left colon -- extremely high mag.jpg | PCM - extremely high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
*Lysozyme +ve.<ref name=pmid12655793>{{cite journal |author=Rubio CA, Nesi G |title=A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections |journal=In Vivo |volume=17 |issue=1 |pages=67–71 |year=2003 |pmid=12655793 |doi= |url=}}</ref> | |||
==See also== | ==See also== | ||
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*[[Inflammatory bowel disease]]. | *[[Inflammatory bowel disease]]. | ||
*[[Colon]]. | *[[Colon]]. | ||
*[[Paneth cell-like change of the prostate gland]]. | |||
==References== | ==References== | ||