Extramammary Paget disease: Difference between revisions
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===DDx=== | ===DDx=== | ||
*[[Malignant melanoma in situ]] - atypical cells are mostly basilar with upward migration. | *[[Malignant melanoma in situ]] - atypical cells are mostly basilar with upward migration. | ||
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Image:Skin MMIS HP 14PY***.jpg|Melanoma in situ - notice that the atypical cells are largely down at the basal layer with some upward migration. (SKB) | Image:Skin MMIS HP 14PY***.jpg|Melanoma in situ - notice that the atypical cells are largely down at the basal layer with some upward migration. (SKB) | ||
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*Squamous cell carcinoma in situ "[[Bowen disease]]" | *Squamous cell carcinoma in situ "[[Bowen disease]]" | ||
**Pagetoid squamous cell carcinoma in situ can look identical to extramammary Paget disease | **Pagetoid squamous cell carcinoma in situ can look identical to extramammary Paget disease | ||
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***Pagetoid squamous cell carcinoma in situ can lose HMW keratins and produce a LMW profile. | ***Pagetoid squamous cell carcinoma in situ can lose HMW keratins and produce a LMW profile. | ||
**Adenocarcinoma markers? - CEA, BerEP4 | **Adenocarcinoma markers? - CEA, BerEP4 | ||
**Nuclear differentiation markers? - p63 or p40 (squamous) vs GATA3 (adnexal) | **Nuclear differentiation markers? - p63 or [[p40]] (squamous) vs GATA3 (adnexal) | ||
*Is the lesion primary or secondary? | *Is the lesion primary or secondary? | ||
**Secondary extramammary Paget disease may be CK20 positive (urothelial or rectal) | **Secondary extramammary Paget disease may be CK20 positive (urothelial or rectal) | ||