Extramammary Paget disease: Difference between revisions
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Image:Penis PagetDisease MP CTR.jpg|Penis Paget Disease - medium power - (SKB) | Image:Penis PagetDisease MP CTR.jpg|Penis Paget Disease - medium power - (SKB) | ||
Image:Penis PagetDisease HP CTR.jpg|Penis Paget Disease - high power - (SKB) | Image:Penis PagetDisease HP CTR.jpg|Penis Paget Disease - high power - (SKB) | ||
Image:Vulva PagetDisease LP Mater.JPG|Vulva Paget Disease - low power - (SKB) | |||
Image:Vulva PagetDisease MP3 Mater.JPG|Vulva Paget Disease - medium power - (SKB) | Image:Vulva PagetDisease MP3 Mater.JPG|Vulva Paget Disease - medium power - (SKB) | ||
Image:Vulva PagetDisease MP Mater.JPG|Vulva Paget Disease - medium power - (SKB) | Image:Vulva PagetDisease MP Mater.JPG|Vulva Paget Disease - medium power - (SKB) | ||
</gallery> | </gallery> | ||
===DDx=== | ===DDx=== | ||
*[[Malignant melanoma in situ]] - atypical cells are mostly basilar with upward migration. | *[[Malignant melanoma in situ]] - atypical cells are mostly basilar with upward migration. | ||
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Image:Skin MMIS HP 14PY***.jpg|Melanoma in situ - notice that the atypical cells are largely down at the basal layer with some upward migration. (SKB) | |||
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*Squamous cell carcinoma in situ "[[Bowen disease]]" | *Squamous cell carcinoma in situ "[[Bowen disease]]" | ||
**Pagetoid squamous cell carcinoma in situ can look identical to extramammary Paget disease | **Pagetoid squamous cell carcinoma in situ can look identical to extramammary Paget disease | ||
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Image:Skin SCCIS PagetoidandConventional 15BR30103.jpg|An SCCIS from sundamaged skin. Pagetoid SCCIS on the left, conventional SCCIS on the right. (SKB) | Image:Skin SCCIS PagetoidandConventional 15BR30103.jpg|An SCCIS from sundamaged skin. Pagetoid SCCIS on the left, conventional SCCIS on the right. (SKB) | ||
</gallery> | </gallery> | ||
*Pagetoid vulvar/anal/penil HPV associated intraepithelial neoplasia - Pagetoid areas often merge into areas of typical VIN | *Pagetoid vulvar/anal/penil HPV associated intraepithelial neoplasia - Pagetoid areas often merge into areas of typical VIN | ||
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***Pagetoid squamous cell carcinoma in situ can lose HMW keratins and produce a LMW profile. | ***Pagetoid squamous cell carcinoma in situ can lose HMW keratins and produce a LMW profile. | ||
**Adenocarcinoma markers? - CEA, BerEP4 | **Adenocarcinoma markers? - CEA, BerEP4 | ||
**Nuclear differentiation markers? - p63 or p40 (squamous) vs GATA3 (adnexal) | **Nuclear differentiation markers? - p63 or [[p40]] (squamous) vs GATA3 (adnexal) | ||
*Is the lesion primary or secondary? | *Is the lesion primary or secondary? | ||
**Secondary extramammary Paget disease may be CK20 positive (urothelial or rectal) | **Secondary extramammary Paget disease may be CK20 positive (urothelial or rectal) | ||