Difference between revisions of "Red blood cell"

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[[Image:Capillary hemangioma - very high mag.jpg|thumb|right|300px|Abundant red blood cells in the vascular channels of a [[hemangioma]]. [[H&E stain|H&E stain]].]]
[[Image:Nucleated_red_blood_cells_-_endometrial_polyp_-_high_mag.jpg|thumb|300px|Nucleated red blood cells in an [[endometrial polyp]]. [[H&E stain]].]]
The '''red blood cell''', abbreviated '''RBC''', is the carrier of oxygen to tissue.  It is seen daily by pathologists.
The '''red blood cell''', abbreviated '''RBC''', is the carrier of oxygen to tissue.  It is seen daily by pathologists.


It is approximately 8 micrometers in diameter.<ref>URL: [http://www.wisegeek.com/how-large-is-a-micrometer.htm http://www.wisegeek.com/how-large-is-a-micrometer.htm]. Accessed on: 17 January 2011.</ref>
It is approximately 8 [[micrometer]]s in diameter.<ref>URL: [http://www.wisegeek.com/how-large-is-a-micrometer.htm http://www.wisegeek.com/how-large-is-a-micrometer.htm]. Accessed on: 17 January 2011.</ref>


==Precursors==
=Precursors=
===Reticulocyte===
===Reticulocyte===
The direct precursor to the RBC is the '''reticulocyte'''.
The direct precursor to the RBC is the '''reticulocyte'''.
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*[http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png Hematopoiesis diagram (WC)].
*[http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png Hematopoiesis diagram (WC)].
*[http://commons.wikimedia.org/wiki/File:Orthochromatic_erythroblast.png Normoblast (WC)].
*[http://commons.wikimedia.org/wiki/File:Orthochromatic_erythroblast.png Normoblast (WC)].
=Conditions with RBCs=
==Sickle cell disease==
{{Main|Sickle cell disease}}
==Anemia==
{{Main|Anemia}}
==Hemophagocytic syndrome==
{{Main|Hemophagocytic syndrome}}
*Macrophages eat whole RBCs.


==Myospherulosis==
==Myospherulosis==
*[[AKA]] ''spherulocytosis''.<ref name=pmid7591868/>
===General===
===General===
*A round aggregrate of RBCs.
*Foreign body-type [[granuloma|granulomatous]] reaction to lipid-containing material and blood.<ref name=pmid7591868/><ref name=pmid11811513>{{Cite journal  | last1 = Fisher | first1 = SC. | last2 = Horning | first2 = GM. | last3 = Hellstein | first3 = JW. | title = Myospherulosis complicating cortical block grafting: a case report. | journal = J Periodontol | volume = 72 | issue = 12 | pages = 1755-9 | month = Dec | year = 2001 | doi = 10.1902/jop.2001.72.12.1755 | PMID = 11811513 }}</ref>
*Granulomatous lesion.<ref name=pmid11811513>{{Cite journal  | last1 = Fisher | first1 = SC. | last2 = Horning | first2 = GM. | last3 = Hellstein | first3 = JW. | title = Myospherulosis complicating cortical block grafting: a case report. | journal = J Periodontol | volume = 72 | issue = 12 | pages = 1755-9 | month = Dec | year = 2001 | doi = 10.1902/jop.2001.72.12.1755 | PMID = 11811513 }}</ref>
*Rare.<ref name=pmid9866916>{{Cite journal  | last1 = Sarkar | first1 = S. | last2 = Gangane | first2 = N. | last3 = Sharma | first3 = S. | title = Myospherulosis of maxillary sinus--a case report with review of literature. | journal = Indian J Pathol Microbiol | volume = 41 | issue = 4 | pages = 491-3 | month = Oct | year = 1998 | doi =  | PMID = 9866916 }}</ref>
*Rare.<ref name=pmid9866916>{{Cite journal  | last1 = Sarkar | first1 = S. | last2 = Gangane | first2 = N. | last3 = Sharma | first3 = S. | title = Myospherulosis of maxillary sinus--a case report with review of literature. | journal = Indian J Pathol Microbiol | volume = 41 | issue = 4 | pages = 491-3 | month = Oct | year = 1998 | doi =  | PMID = 9866916 }}</ref>


Etiology:
Etiology:
*Exposure to dying fat, e.g. [[fat necrosis of the breast]].
*Exposure to dying fat,<ref name=pmid7591868>{{Cite journal  | last1 = Godbersen | first1 = GS. | last2 = Kleeberg | first2 = J. | last3 = Lüttges | first3 = J. | last4 = Werner | first4 = JA. | title = [Spherulocytosis (myospherulosis) of the paranasal sinuses]. | journal = HNO | volume = 43 | issue = 9 | pages = 552-5 | month = Sep | year = 1995 | doi =  | PMID = 7591868 }}</ref> e.g. [[fat necrosis of the breast]].
*Malignancy, e.g. [[renal cell carcinoma]].<ref name=pmid11035579>{{Cite journal  | last1 = Chau | first1 = KY. | last2 = Pretorius | first2 = JM. | last3 = Stewart | first3 = AW. | title = Myospherulosis in renal cell carcinoma. | journal = Arch Pathol Lab Med | volume = 124 | issue = 10 | pages = 1476-9 | month = Oct | year = 2000 | doi = 10.1043/0003-9985(2000)1241476:MIRCC2.0.CO;2 | PMID = 11035579 }}</ref>
*Malignancy, e.g. [[renal cell carcinoma]].<ref name=pmid11035579>{{Cite journal  | last1 = Chau | first1 = KY. | last2 = Pretorius | first2 = JM. | last3 = Stewart | first3 = AW. | title = Myospherulosis in renal cell carcinoma. | journal = Arch Pathol Lab Med | volume = 124 | issue = 10 | pages = 1476-9 | month = Oct | year = 2000 | doi = 10.1043/0003-9985(2000)1241476:MIRCC2.0.CO;2 | PMID = 11035579 }}</ref>


===Microscopic===
===Microscopic===
Features:
Features:
*Round aggregates of red blood cells ~10-20 RBCs in diameter (80-160 micrometers).
*Phagocytosed RBCs.
**Round aggregates of red blood cells ~10-20 RBCs in diameter (80-160 micrometers).


==See also==
=See also=
*[[Neutrophil]].
*[[Neutrophil]].
*[[Eosinophil]].
*[[Red blood cell extravasation]].
*[[Amebiasis]].


==References==
=References=
{{Reflist|1}}
{{Reflist|2}}


[[Category:Basics]]
[[Category:Basics]]

Latest revision as of 11:09, 25 November 2016

Abundant red blood cells in the vascular channels of a hemangioma. H&E stain.
Nucleated red blood cells in an endometrial polyp. H&E stain.

The red blood cell, abbreviated RBC, is the carrier of oxygen to tissue. It is seen daily by pathologists.

It is approximately 8 micrometers in diameter.[1]

Precursors

Reticulocyte

The direct precursor to the RBC is the reticulocyte.

Image:

Normoblast

Normoblasts are the nucleated precursors of RBCs.

Images:

Conditions with RBCs

Sickle cell disease

Main article: Sickle cell disease

Anemia

Main article: Anemia

Hemophagocytic syndrome

Main article: Hemophagocytic syndrome
  • Macrophages eat whole RBCs.

Myospherulosis

General

Etiology:

Microscopic

Features:

  • Phagocytosed RBCs.
    • Round aggregates of red blood cells ~10-20 RBCs in diameter (80-160 micrometers).

See also

References

  1. ↑ URL: http://www.wisegeek.com/how-large-is-a-micrometer.htm. Accessed on: 17 January 2011.
  2. ↑ 2.0 2.1 2.2 Godbersen, GS.; Kleeberg, J.; Lüttges, J.; Werner, JA. (Sep 1995). "[Spherulocytosis (myospherulosis) of the paranasal sinuses].". HNO 43 (9): 552-5. PMID 7591868.
  3. ↑ Fisher, SC.; Horning, GM.; Hellstein, JW. (Dec 2001). "Myospherulosis complicating cortical block grafting: a case report.". J Periodontol 72 (12): 1755-9. doi:10.1902/jop.2001.72.12.1755. PMID 11811513.
  4. ↑ Sarkar, S.; Gangane, N.; Sharma, S. (Oct 1998). "Myospherulosis of maxillary sinus--a case report with review of literature.". Indian J Pathol Microbiol 41 (4): 491-3. PMID 9866916.
  5. ↑ Chau, KY.; Pretorius, JM.; Stewart, AW. (Oct 2000). "Myospherulosis in renal cell carcinoma.". Arch Pathol Lab Med 124 (10): 1476-9. doi:10.1043/0003-9985(2000)1241476:MIRCC2.0.CO;2. PMID 11035579.
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