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Difference between revisions of "Red blood cell"
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[[Image:Capillary hemangioma - very high mag.jpg|thumb|right|300px|Abundant red blood cells in the vascular channels of a [[hemangioma]]. [[H&E stain|H&E stain]].]] | |||
[[Image:Nucleated_red_blood_cells_-_endometrial_polyp_-_high_mag.jpg|thumb|300px|Nucleated red blood cells in an [[endometrial polyp]]. [[H&E stain]].]] | |||
The '''red blood cell''', abbreviated '''RBC''', is the carrier of oxygen to tissue. It is seen daily by pathologists. | The '''red blood cell''', abbreviated '''RBC''', is the carrier of oxygen to tissue. It is seen daily by pathologists. | ||
It is approximately 8 | It is approximately 8 [[micrometer]]s in diameter.<ref>URL: [http://www.wisegeek.com/how-large-is-a-micrometer.htm http://www.wisegeek.com/how-large-is-a-micrometer.htm]. Accessed on: 17 January 2011.</ref> | ||
=Precursors= | |||
===Reticulocyte=== | ===Reticulocyte=== | ||
The direct precursor to the RBC is the '''reticulocyte'''. | The direct precursor to the RBC is the '''reticulocyte'''. | ||
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*[http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png Hematopoiesis diagram (WC)]. | *[http://commons.wikimedia.org/wiki/File:Hematopoiesis_%28human%29_diagram.png Hematopoiesis diagram (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Orthochromatic_erythroblast.png Normoblast (WC)]. | *[http://commons.wikimedia.org/wiki/File:Orthochromatic_erythroblast.png Normoblast (WC)]. | ||
=Conditions with RBCs= | |||
==Sickle cell disease== | |||
{{Main|Sickle cell disease}} | |||
==Anemia== | |||
{{Main|Anemia}} | |||
==Hemophagocytic syndrome== | |||
{{Main|Hemophagocytic syndrome}} | |||
*Macrophages eat whole RBCs. | |||
==Myospherulosis== | ==Myospherulosis== | ||
*[[AKA]] ''spherulocytosis''.<ref name=pmid7591868/> | |||
===General=== | ===General=== | ||
* | *Foreign body-type [[granuloma|granulomatous]] reaction to lipid-containing material and blood.<ref name=pmid7591868/><ref name=pmid11811513>{{Cite journal | last1 = Fisher | first1 = SC. | last2 = Horning | first2 = GM. | last3 = Hellstein | first3 = JW. | title = Myospherulosis complicating cortical block grafting: a case report. | journal = J Periodontol | volume = 72 | issue = 12 | pages = 1755-9 | month = Dec | year = 2001 | doi = 10.1902/jop.2001.72.12.1755 | PMID = 11811513 }}</ref> | ||
*Rare.<ref name=pmid9866916>{{Cite journal | last1 = Sarkar | first1 = S. | last2 = Gangane | first2 = N. | last3 = Sharma | first3 = S. | title = Myospherulosis of maxillary sinus--a case report with review of literature. | journal = Indian J Pathol Microbiol | volume = 41 | issue = 4 | pages = 491-3 | month = Oct | year = 1998 | doi = | PMID = 9866916 }}</ref> | |||
Etiology: | Etiology: | ||
*Exposure to dying fat, e.g. [[fat necrosis of the breast]]. | *Exposure to dying fat,<ref name=pmid7591868>{{Cite journal | last1 = Godbersen | first1 = GS. | last2 = Kleeberg | first2 = J. | last3 = Lüttges | first3 = J. | last4 = Werner | first4 = JA. | title = [Spherulocytosis (myospherulosis) of the paranasal sinuses]. | journal = HNO | volume = 43 | issue = 9 | pages = 552-5 | month = Sep | year = 1995 | doi = | PMID = 7591868 }}</ref> e.g. [[fat necrosis of the breast]]. | ||
*Malignancy, e.g. [[renal cell carcinoma]].<ref name=pmid11035579>{{Cite journal | last1 = Chau | first1 = KY. | last2 = Pretorius | first2 = JM. | last3 = Stewart | first3 = AW. | title = Myospherulosis in renal cell carcinoma. | journal = Arch Pathol Lab Med | volume = 124 | issue = 10 | pages = 1476-9 | month = Oct | year = 2000 | doi = 10.1043/0003-9985(2000)1241476:MIRCC2.0.CO;2 | PMID = 11035579 }}</ref> | *Malignancy, e.g. [[renal cell carcinoma]].<ref name=pmid11035579>{{Cite journal | last1 = Chau | first1 = KY. | last2 = Pretorius | first2 = JM. | last3 = Stewart | first3 = AW. | title = Myospherulosis in renal cell carcinoma. | journal = Arch Pathol Lab Med | volume = 124 | issue = 10 | pages = 1476-9 | month = Oct | year = 2000 | doi = 10.1043/0003-9985(2000)1241476:MIRCC2.0.CO;2 | PMID = 11035579 }}</ref> | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Round aggregates of red blood cells ~10-20 RBCs in diameter (80-160 micrometers). | *Phagocytosed RBCs. | ||
**Round aggregates of red blood cells ~10-20 RBCs in diameter (80-160 micrometers). | |||
=See also= | |||
*[[Neutrophil]]. | *[[Neutrophil]]. | ||
*[[Eosinophil]]. | |||
*[[Red blood cell extravasation]]. | |||
*[[Amebiasis]]. | |||
=References= | |||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Basics]] | [[Category:Basics]] | ||