Difference between revisions of "Fetal thrombotic vasculopathy"

Jump to navigation Jump to search

Fetal thrombotic vasculopathy (view source)

Revision as of 22:35, 14 November 2016

5,655 bytes added ,  22:35, 14 November 2016
m
tweak
(+cat.)
m (tweak)
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
#redirect [[Placenta#Fetal_thrombotic_vasculopathy]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Fetal_thrombotic_vasculopathy_-_intermed_mag.jpg
| Width      =
| Caption    = Fetal thrombotic vasculopathy. [[H&E stain]].
| Synonyms  = fibrinous vasculosis, fibromuscular sclerosis, fetal artery stem thrombosis
| Micro      = thrombus in the fetal vasculature +/- recanalization (eosinophilic (light pink on H&E), moderately granular intravascular material (fibrin) with layering), +/-clustered fibrotic villi without blood vessels (chronic)
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[placenta]]
| Assdx      = fetal death, cerebral palsy
| Syndromes  =
| Clinicalhx = +/-prothrombotic condition in mother
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = dependent on severity and underlying cause
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Fetal thrombotic vasculopathy''', abbreviated '''FTV''', is characterized by thrombi in the fetus.  In the context of a [[placenta]], it is thrombi in the fetal [[blood vessel]]s of the placenta.


A large number of terms are used for this including:<ref name=pmid19237859>{{Cite journal  | last1 = Marchetti | first1 = D. | last2 = Belviso | first2 = M. | last3 = Fulcheri | first3 = E. | title = A case of stillbirth: the importance of placental investigation in medico-legal practice. | journal = Am J Forensic Med Pathol | volume = 30 | issue = 1 | pages = 64-8 | month = Mar | year = 2009 | doi = 10.1097/PAF.0b013e318187387e | PMID = 19237859 }}</ref> '''fibrinous vasculosis''', '''fibromuscular sclerosis''' and '''fetal artery stem thrombosis'''.
The multitude of terms reflects the confusion about this finding and that it has numerous etiologies.<ref name=pmid19237859/>
==General==
*May cause [[IUGR]].
*Associated with cerebral palsy and common in perinatal deaths.<ref name=pmid10414494>{{Cite journal  | last1 = Kraus | first1 = FT. | last2 = Acheen | first2 = VI. | title = Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. | journal = Hum Pathol | volume = 30 | issue = 7 | pages = 759-69 | month = Jul | year = 1999 | doi =  | PMID = 10414494 }}</ref>
*Mother may have a prothrombotic condition.<ref name=pmid24108664>{{Cite journal  | last1 = Magnetti | first1 = F. | last2 = Bagna | first2 = R. | last3 = Botta | first3 = G. | last4 = Viano | first4 = A. | last5 = Dorati | first5 = G. | last6 = Raia | first6 = M. | last7 = Bertino | first7 = E. | last8 = Saracco | first8 = P. | title = Fetal Thrombotic Vasculopathy and Perinatal Thrombosis: Should all Placentas be Examined? | journal = Am J Perinatol | volume =  | issue =  | pages =  | month = Oct | year = 2013 | doi = 10.1055/s-0033-1357267 | PMID = 24108664 }}</ref>
==Microscopic==
Features:<ref name=pmid10414494>{{Cite journal  | last1 = Kraus | first1 = FT. | last2 = Acheen | first2 = VI. | title = Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. | journal = Hum Pathol | volume = 30 | issue = 7 | pages = 759-69 | month = Jul | year = 1999 | doi =  | PMID = 10414494 }}</ref>
*Thrombus in the fetal vasculature +/- recanalization.
**Eosinophilic (light pink on H&E), moderately granular intravascular material (fibrin) with layering.
*Clustered fibrotic villi without blood vessels - '''key feature'''.
**This is a chronic change.
===Images===
Case 1:
<gallery>
Image: Fetal thrombotic vasculopathy - low mag.jpg | FTV - low mag. (WC)
Image: Fetal thrombotic vasculopathy - intermed mag.jpg | FTV - intermed. mag. (WC)
Image: Fetal thrombotic vasculopathy - high mag.jpg | FTV - high mag. (WC)
Image: Fetal thrombotic vasculopathy - very high mag.jpg | FTV - very high mag. (WC)
</gallery>
Case 2:
<gallery>
Image: Fetal thrombotic vasculopathy -- low mag.jpg | FTV - low mag. (WC)
Image: Fetal thrombotic vasculopathy -- intermed mag.jpg | FTV - intermed mag. (WC)
Image: Fetal thrombotic vasculopathy - alt -- intermed mag.jpg | FTV - intermed mag. (WC)
Image: Fetal thrombotic vasculopathy -- high mag.jpg | FTV - high mag. (WC)
</gallery>
www:
*[http://jcp.bmj.com/content/61/12/1254/F8.large.jpg FTV (bmj.com)].<ref>URL: [http://jcp.bmj.com/content/61/12/1254.abstract http://jcp.bmj.com/content/61/12/1254.abstract]. Accessed on: 12 January 2011.</ref>
*[http://gut.bmj.com/content/41/3/354/F3.large.jpg Thrombus - rat (bmj.com)].<ref>URL: [http://gut.bmj.com/content/41/3/354.full http://gut.bmj.com/content/41/3/354.full]. Accessed on: 12 January 2011.</ref>
*[http://www.womenandinfants.org/fertilityandpregnancy/images/FTV.Fig.4a.jpg FTV - low mag. (womenandinfants.org)].<ref>URL: [http://www.womenandinfants.org/fertilityandpregnancy/current-topics-in-perinatal-pathology.cfm http://www.womenandinfants.org/fertilityandpregnancy/current-topics-in-perinatal-pathology.cfm]. Accessed on: 17 December 2012.</ref>
*[http://www.womenandinfants.org/fertilityandpregnancy/images/FTV.Fig.4b.jpg FTV - high mag. (womenandinfants.org)].
==Sign out==
<pre>
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
- FETAL THROMBOTIC VASCULOPATHY, SEE COMMENT.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI INCREASED PERIVILLOUS FIBRIN DEPOSITION
  AND CALCIFICATIONS.
- PLACENTAL INFARCT (1.5 CM IN MAXIMAL DIMENSION).
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
COMMENT:
Mother and baby should be worked up for prothrombotic conditions.
</pre>
==See also==
*[[Placenta]].
*[[Systemic lupus erythematosus]].
==References==
{{Reflist|2}}
[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Placenta]]
Michael
49,012

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/8469...46213"

Navigation menu