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Difference between revisions of "Adenocarcinoma of the urinary bladder"
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Adenocarcinoma of the urinary bladder (view source)
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| LMDDx = [[urachal carcinoma]], invasive [[urothelial carcinoma]] with glandular differentiation, [[metastatic]] adenocarcinoma, direct extension of [[adenocarcinoma]] from an adjacent structure (esp. [[colorectal adenocarcinoma]]) | | LMDDx = [[urachal carcinoma]], invasive [[urothelial carcinoma]] with glandular differentiation, [[metastatic]] adenocarcinoma, direct extension of [[adenocarcinoma]] from an adjacent structure (esp. [[colorectal adenocarcinoma]]) | ||
| Stains = | | Stains = | ||
| IHC = CK7 +ve, CK20 +ve, CDX2 +ve (strong, diffuse), beta-catenin | | IHC = CK7 +ve, CK20 +ve, CDX2 +ve (strong, diffuse), beta-catenin -ve (nuclei -ve, membranes +ve) | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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**[[Prostatic adenocarcinoma]] - esp. [[ductal adenocarcinoma of the prostate]]. | **[[Prostatic adenocarcinoma]] - esp. [[ductal adenocarcinoma of the prostate]]. | ||
**[[Endometrioid endometrial adenocarcinoma]]. | **[[Endometrioid endometrial adenocarcinoma]]. | ||
*[[Tubular adenoma of the urinary tract]].<ref name=pmid23664485>{{Cite journal | last1 = Kao | first1 = CS. | last2 = Epstein | first2 = JI. | title = Tubular adenoma of the urinary tract: a newly described entity. | journal = Hum Pathol | volume = 44 | issue = 9 | pages = 1890-4 | month = Sep | year = 2013 | doi = 10.1016/j.humpath.2013.02.017 | PMID = 23664485 }}</ref> | |||
===Images=== | ===Images=== | ||
====Case 1==== | ====Case 1==== | ||
<gallery> | <gallery> | ||
Image: Adenocarcinoma of the urinary bladder -- low mag.jpg | AUB - low mag. (WC) | Image: Adenocarcinoma of the urinary bladder -- low mag.jpg | Invasive AUB - low mag. (WC) | ||
Image: Adenocarcinoma of the urinary bladder -- intermed mag.jpg | AUB - intermed. mag. (WC) | Image: Adenocarcinoma of the urinary bladder -- intermed mag.jpg | Invasive AUB - intermed. mag. (WC) | ||
Image: Adenocarcinoma of the urinary bladder -- high mag.jpg | AUB - high mag. (WC) | Image: Adenocarcinoma of the urinary bladder -- high mag.jpg | Invasive AUB - high mag. (WC) | ||
</gallery> | |||
====Case 2 - AIS==== | |||
<gallery> | |||
Image: Adenocarcinoma in situ of bladder -- very low mag.jpg | Adenocarcinoma in situ (AIS) - very low mag. | |||
Image: Adenocarcinoma in situ of bladder -- low mag.jpg | AIS - low mag. | |||
Image: Adenocarcinoma in situ of bladder -- intermed mag.jpg | AIS - intermed. mag. | |||
Image: Adenocarcinoma in situ of bladder -- high mag.jpg | AIS - high mag. | |||
</gallery> | </gallery> | ||
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*CK20 +ve. | *CK20 +ve. | ||
*CDX2 +ve (strong, diffuse). | *CDX2 +ve (strong, diffuse). | ||
*Beta-catenin | *Beta-catenin -ve (negative nuclear staining, positive membranous staining). | ||
**[[Colorectal adenocarcinoma]] typically has nuclear staining ''and'' membranous staining. | **[[Colorectal adenocarcinoma]] typically has nuclear staining ''and'' membranous staining. | ||
*Thrombomodulin +ve/-ve (~60% of cases). | *Thrombomodulin +ve/-ve (~60% of cases). | ||