Difference between revisions of "Glioblastoma"

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312 bytes added ,  07:55, 20 September 2016
→‎Molecular: pediatric GBM
(→‎Microscopic: fix ref)
(→‎Molecular: pediatric GBM)
Line 162: Line 162:
**PI3K-pathway genes (7-10%).
**PI3K-pathway genes (7-10%).


*Pediatric glioblastoma
**are morphologically indistinct from adult GBM.
**show frequent H3F3A mutations  and PDGFRA mutations (Note: H3F3A K27M mutations are classified as [[Astrocytoma#H3.3_K27M_mutated_glioma_of_the_midline|K27 mutated midline glioma]]).
**Consider Epithelioid GBM, when BRAF V600E mutated.


*Diagnostic/therapeutic relevant markers:
*Diagnostic/therapeutic relevant markers:
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