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Difference between revisions of "Mucinous breast carcinoma"
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Mucinous breast carcinoma (view source)
Revision as of 11:37, 8 September 2016
, 11:37, 8 September 2016no edit summary
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| IF = | | IF = | ||
| Gross = pale, glistening, jelly-like appearance | | Gross = pale, glistening, jelly-like appearance | ||
| Grossing = | | Grossing = [[breast grossing]] | ||
| Staging = [[breast cancer staging]] | |||
| Site = [[breast]] - see ''[[invasive breast cancer]]'' | | Site = [[breast]] - see ''[[invasive breast cancer]]'' | ||
| Assdx = | | Assdx = | ||
| Line 36: | Line 37: | ||
==General== | ==General== | ||
*Rare. | *Rare. | ||
*2% of invasive breast carcinomas. | |||
*Good prognosis.<ref name=pmid18809061>{{Cite journal | last1 = Barkley | first1 = CR. | last2 = Ligibel | first2 = JA. | last3 = Wong | first3 = JS. | last4 = Lipsitz | first4 = S. | last5 = Smith | first5 = BL. | last6 = Golshan | first6 = M. | title = Mucinous breast carcinoma: a large contemporary series. | journal = Am J Surg | volume = 196 | issue = 4 | pages = 549-51 | month = Oct | year = 2008 | doi = 10.1016/j.amjsurg.2008.06.013 | PMID = 18809061 }}</ref> | *Good prognosis.<ref name=pmid18809061>{{Cite journal | last1 = Barkley | first1 = CR. | last2 = Ligibel | first2 = JA. | last3 = Wong | first3 = JS. | last4 = Lipsitz | first4 = S. | last5 = Smith | first5 = BL. | last6 = Golshan | first6 = M. | title = Mucinous breast carcinoma: a large contemporary series. | journal = Am J Surg | volume = 196 | issue = 4 | pages = 549-51 | month = Oct | year = 2008 | doi = 10.1016/j.amjsurg.2008.06.013 | PMID = 18809061 }}</ref> | ||
*Usually older women. | *Usually older women. | ||
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**Glands typically have irregular edges. | **Glands typically have irregular edges. | ||
**+/-Vessels within the mucin pools. | **+/-Vessels within the mucin pools. | ||
*Subtypes <ref>{{Cite journal | last1 = Weigelt | first1 = B. | last2 = Geyer | first2 = FC. | last3 = Horlings | first3 = HM. | last4 = Kreike | first4 = B. | last5 = Halfwerk | first5 = H. | last6 = Reis-Filho | first6 = JS. | title = Mucinous and neuroendocrine breast carcinomas are transcriptionally distinct from invasive ductal carcinomas of no special type. | journal = Mod Pathol | volume = 22 | issue = 11 | pages = 1401-14 | month = Nov | year = 2009 | doi = 10.1038/modpathol.2009.112 | PMID = 19633645 }}</ref> | |||
**Mucinous A (or paucicellular) - more mucin | |||
**Mucinous B (or hypercellular) - less mucin and neuroendocrine differentiation and argyrophilia | |||
DDx: | DDx: | ||
*[[DCIS]] with a mucinous component. | *[[DCIS]] with a mucinous component. | ||
**Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border. | **Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border. | ||
*[[Invasive ductal carcinoma of the breast]] with a mucinous component - more common than ''mucinous breast carcinoma''. Any 'no special type' component imparts a worse prognosis so the diagnosis 'mucinous carcinoma' is reserved for tumours with pure mucinous features. | *[[Invasive ductal carcinoma of the breast]] with a mucinous component - more common than ''mucinous breast carcinoma''. Any 'no special type' component imparts a worse prognosis so the diagnosis 'mucinous carcinoma' is reserved for tumours with close to pure mucinous features. | ||
Note: | Note: | ||