Difference between revisions of "Mixed epithelial and stromal tumour of the kidney"

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==IHC==
==IHC==
Features:<ref name=pmid17454754>{{Cite journal  | last1 = Mai | first1 = KT. | last2 = Elkeilani | first2 = A. | last3 = Veinot | first3 = JP. | title = Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis. | journal = Pathology | volume = 39 | issue = 2 | pages = 235-40 | month = Apr | year = 2007 | doi = 10.1080/00313020701230799 | PMID = 17454754 }}
Features:<ref name=pmid17454754>{{Cite journal  | last1 = Mai | first1 = KT. | last2 = Elkeilani | first2 = A. | last3 = Veinot | first3 = JP. | title = Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis. | journal = Pathology | volume = 39 | issue = 2 | pages = 235-40 | month = Apr | year = 2007 | doi = 10.1080/00313020701230799 | PMID = 17454754 }}</ref>
</ref>
*ER +ve.
*ER +ve.
*PR +ve.
*PR +ve.

Revision as of 20:54, 18 August 2016

Mixed epithelial and stromal tumour of the kidney
Diagnosis in short

Mixed epithelial stromal tumour of kidney. H&E stain.
LM cysts lined by simple epithelium with hobnailing, stroma has an ovarian look (basophilic, spindle cells)
LM DDx cystic nephroma, tubulocystic renal cell carcinoma
IHC ER +ve, PR +ve, CD10 +ve
Gross renal mass, predominantly solid
Grossing notes total nephrectomy for tumour grossing, partial nephrectomy grossing
Site kidney - see kidney tumour
Prevalence rare
Prognosis benign

Mixed epithelial and stromal tumour of the kidney, abbreviated MEST, is a rare benign kidney tumour in the WHO classification of renal neoplasia.

Turbiner et al.[1] have suggested that cystic nephroma and mixed epithelial and stromal tumour (MEST) are one tumour; the proposed lumping term renal epithelial and stromal tumour, abbreviated REST.

General

  • Rare - approximately 1.5% of renal neoplasms.[2]
  • Benign.
  • Prevalence: males > females.

Gross

  • Solid and cystic mass - predominantly solid.

Microscopic

Features:

  • Cysts lined by simple epithelium with hobnailing - key feature.
  • Stroma has an ovarian look:
    • Blue (basophilic).
    • Spindle cells.

Notes:

  • Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts.

DDx:

Images

  • MEST - low mag.

  • MEST - intermed. mag.

  • MEST - high mag.

  • MEST - high mag.

  • MEST - very high mag.

IHC

Features:[2]

  • ER +ve.
  • PR +ve.
  • CD10 +ve.

See also

References

  1. ↑ Turbiner, J.; Amin, MB.; Humphrey, PA.; Srigley, JR.; De Leval, L.; Radhakrishnan, A.; Oliva, E. (Apr 2007). "Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term.". Am J Surg Pathol 31 (4): 489-500. doi:10.1097/PAS.0b013e31802bdd56. PMID 17414095.
  2. ↑ 2.0 2.1 Mai, KT.; Elkeilani, A.; Veinot, JP. (Apr 2007). "Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis.". Pathology 39 (2): 235-40. doi:10.1080/00313020701230799. PMID 17454754.
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