Difference between revisions of "Sudden natural death"

From Libre Pathology
Jump to navigation Jump to search
 
(17 intermediate revisions by the same user not shown)
Line 3: Line 3:
==By system==
==By system==
===Respiratory<ref name=pmid16410164>{{cite journal |author=de la Grandmaison GL |title=Is there progress in the autopsy diagnosis of sudden unexpected death in adults? |journal=Forensic Sci. Int. |volume=156 |issue=2-3 |pages=138–44 |year=2006 |month=January |pmid=16410164 |doi=10.1016/j.forsciint.2004.12.024 |url=}}</ref>===
===Respiratory<ref name=pmid16410164>{{cite journal |author=de la Grandmaison GL |title=Is there progress in the autopsy diagnosis of sudden unexpected death in adults? |journal=Forensic Sci. Int. |volume=156 |issue=2-3 |pages=138–44 |year=2006 |month=January |pmid=16410164 |doi=10.1016/j.forsciint.2004.12.024 |url=}}</ref>===
*Anaphylaxis.  
*[[Anaphylaxis]].  
*[[Asthma]].
*[[Asthma]].
*[[Pulmonary embolism]].
*[[Pulmonary embolism]].


===Cerebral===
===Cerebral===
*SUDEP (sudden unexpected death in epilepsy).
*[[SUDEP]] (sudden unexpected death in [[epilepsy]]).


===Cardiac===
===Sudden cardiac death===
====Older====
====Older====
*Atherosclerotic heart disease (ASHD); [[AKA]] coronary artery disease (CAD).  
*[[Atherosclerotic heart disease]] (ASHD); [[AKA]] coronary artery disease (CAD).  
*[[Hypertension]] - a heart > ~400 g is considered good enough if nothing else is present.<ref>MSP. 29 September 2010.</ref>
*[[Hypertensive heart disease]] - a heart > ~400 g is considered good enough if nothing else is present.<ref>MSP. 29 September 2010.</ref>


====Younger====
====Younger====
*Right ventricular cardiomyopathy.
*[[Arrhythmogenic right ventricular cardiomyopathy]].
*Dilated [[cardiomyopathy]].
*[[Hypertrophic cardiomyopathy]], e.g. [[hypertrophic obstructive cardiomyopathy]] (HOCM).


Notes:
Notes:
*The mechanism is usually arrhythmia; this is usually not provable at autopsy.
*The mechanism is usually [[cardiac arrhythmia|arrhythmia]].
**Generally, this is usually not provable at [[autopsy]]; however, some findings have been proposed.<ref name=pmid15837088>{{Cite journal  | last1 = Baroldi | first1 = G. | last2 = Silver | first2 = MD. | last3 = Parolini | first3 = M. | last4 = Pomara | first4 = C. | last5 = Turillazzi | first5 = E. | last6 = Fineschi | first6 = V. | title = Myofiberbreak-up: a marker of ventricular fibrillation in sudden cardiac death. | journal = Int J Cardiol | volume = 100 | issue = 3 | pages = 435-41 | month = Apr | year = 2005 | doi = 10.1016/j.ijcard.2004.10.007 | PMID = 15837088 }}</ref>


====Detailed cardiac<ref name=pmid16410164/>====
====Detailed cardiac<ref name=pmid16410164/>====
*ASHD,
*[[ASHD]].
*Cardiomyopathy.
*[[Cardiomyopathy]].
**Hypertrophic CM.
**[[Hypertrophic cardiomyopathy]].
**[[Arrhythmogenic right ventricular cardiomyopathy]] (ARVCM).
**[[Arrhythmogenic right ventricular cardiomyopathy]] (ARVC).
**Dilated [[cardiomyopathy]] (DCM).
**[[Dilated cardiomyopathy]] (DCM).
*Lymphocytic myocarditis.  
*[[Lymphocytic myocarditis]].  
*Floppy mitral valve (MV).
*[[Floppy mitral valve]].
*Aortic valve stenosis.
*[[Aortic valve stenosis]].
*Congenital cardiac abnormality.
*Congenital cardiac abnormality.
*Coronary artery dissection.  
*Coronary artery dissection.  
*Aortic dissection.
*[[Aortic dissection]].
*Arrhythmia.<ref>URL: [http://www.sads.org.uk/causes_of_sads.htm http://www.sads.org.uk/causes_of_sads.htm]. Accessed on: 29 September 2010.</ref>  
*[[Cardic arrhythmia|Arrhythmia]].<ref>URL: [http://www.sads.org.uk/causes_of_sads.htm http://www.sads.org.uk/causes_of_sads.htm]. Accessed on: 29 September 2010.</ref>  
**Long QT syndrome.  
**Long QT syndrome.  
**Brugada syndrome.  
**Brugada syndrome.  
Line 44: Line 45:
**Sodium channel disease.
**Sodium channel disease.
**Idiopathic ventricular fibrillation.
**Idiopathic ventricular fibrillation.
*Tumours.
**[[Cystic tumour of the atrioventricular nodal region]].


Post-mortem (molecular) testing for arrhythmias:<ref>MSP. 29 September 2010:</ref>
Post-mortem (molecular) testing for arrhythmias:<ref>MSP. 29 September 2010:</ref>
Line 54: Line 57:
*Ruptured AAA.
*Ruptured AAA.
*Peptic ulcer.  
*Peptic ulcer.  
*Cerebral aneurysm.
*[[Cerebral aneurysm]].


==See also==
==See also==
*[[Forensic pathology]].
*[[Forensic pathology]].
*[[Channelopathies]].


==Reference==
==Reference==
{{reflist|1}}
{{reflist|2}}


[[Category:Autopsy]]
[[Category:Autopsy]]

Latest revision as of 05:18, 21 July 2016

Sudden natural death happens. It must be differentiated from other ways of dying (suicide, homicide, accidental).

By system

Respiratory[1]

Cerebral

Sudden cardiac death

Older

Younger

Notes:

  • The mechanism is usually arrhythmia.
    • Generally, this is usually not provable at autopsy; however, some findings have been proposed.[3]

Detailed cardiac[1]

Post-mortem (molecular) testing for arrhythmias:[5]

  • CPVT.
  • Sodium channel disease.
  • Brugada syndrome.

By mechanism

Hemorrhagic[1]

See also

Reference

  1. 1.0 1.1 1.2 de la Grandmaison GL (January 2006). "Is there progress in the autopsy diagnosis of sudden unexpected death in adults?". Forensic Sci. Int. 156 (2-3): 138–44. doi:10.1016/j.forsciint.2004.12.024. PMID 16410164.
  2. MSP. 29 September 2010.
  3. Baroldi, G.; Silver, MD.; Parolini, M.; Pomara, C.; Turillazzi, E.; Fineschi, V. (Apr 2005). "Myofiberbreak-up: a marker of ventricular fibrillation in sudden cardiac death.". Int J Cardiol 100 (3): 435-41. doi:10.1016/j.ijcard.2004.10.007. PMID 15837088.
  4. URL: http://www.sads.org.uk/causes_of_sads.htm. Accessed on: 29 September 2010.
  5. MSP. 29 September 2010: