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Difference between revisions of "Cholangiocarcinoma"
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*''MUC-1'' is also known as ''[[EMA]]''. | *''MUC-1'' is also known as ''[[EMA]]''. | ||
==Molecular== | |||
*Approx. 10% of the tumors carry a [[IDH-1]] or IDH-2 hotspot mutation.<ref>{{Cite journal | last1 = Wang | first1 = P. | last2 = Dong | first2 = Q. | last3 = Zhang | first3 = C. | last4 = Kuan | first4 = PF. | last5 = Liu | first5 = Y. | last6 = Jeck | first6 = WR. | last7 = Andersen | first7 = JB. | last8 = Jiang | first8 = W. | last9 = Savich | first9 = GL. | title = Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. | journal = Oncogene | volume = 32 | issue = 25 | pages = 3091-100 | month = Jun | year = 2013 | doi = 10.1038/onc.2012.315 | PMID = 22824796 }}</ref> | |||
*FGFR2 gene fusions have been reported.<ref>{{Cite journal | last1 = Wu | first1 = YM. | last2 = Su | first2 = F. | last3 = Kalyana-Sundaram | first3 = S. | last4 = Khazanov | first4 = N. | last5 = Ateeq | first5 = B. | last6 = Cao | first6 = X. | last7 = Lonigro | first7 = RJ. | last8 = Vats | first8 = P. | last9 = Wang | first9 = R. | title = Identification of targetable FGFR gene fusions in diverse cancers. | journal = Cancer Discov | volume = 3 | issue = 6 | pages = 636-47 | month = Jun | year = 2013 | doi = 10.1158/2159-8290.CD-13-0050 | PMID = 23558953 }}</ref> | |||
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