Focal nodular hyperplasia: Difference between revisions
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Focal_nodular_hyperplasia_-_intermed_mag.jpg | |||
| Width = | |||
| Caption = Focal nodular hyperplasia. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = thick walled blood vessels without bile ducts of same size, bile ductular proliferation at the edge of the fibrosis tissue | |||
| Subtypes = | |||
| LMDDx = [[hepatic adenoma]], [[cirrhosis]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = well circumscribed with capsule, lighter than surrounding parenchyma - may be yellow, +/-stellate central scar with thick vessels | |||
| Grossing = | |||
| Site = [[liver]] - see ''[[medical liver disease]]'' | |||
| Assdx = | |||
| Syndromes = [[hereditary hemorrhagic telangiectasia]] | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = usu. solitary lesion, arterial phase enhancement in triphasic imaging | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Focal nodular hyperplasia''', abbreviated '''FNH''', is a benign [[liver]] lesion, uncommonly seen by pathologists. | '''Focal nodular hyperplasia''', abbreviated '''FNH''', is a benign [[liver]] lesion, uncommonly seen by pathologists. | ||
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*Lighter than surrounding parenchyma, may be yellow. | *Lighter than surrounding parenchyma, may be yellow. | ||
*+/-Stellate central scar with thick vessels. | *+/-Stellate central scar with thick vessels. | ||
**Can be identified on | **Can be identified on medical imaging. | ||
Note: Usually a solitary lesion.<ref name=emedicine_fnh/> | Note: Usually a solitary lesion.<ref name=emedicine_fnh/> | ||
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www: | www: | ||
*[http://path.upmc.edu/cases/case444.html FNH - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case444.html FNH - several images (upmc.edu)]. | ||
{| | |||
[[File:1 FNH 1 680x512px.tif|Trichrome shows fibrous scar with vessels/bile ductules (40X)]] | |||
[[File:2 FNH 1 680x512px.tif|PAS-D shows tortuous bile ductules at edge of scar with minimal inflammation (200X)]] | |||
[[File:3 FNH 1 680x512px.tif|PAS-D shows proliferated blood vessels in center of scar with minimal inflammation (200X).]] | |||
[[File:4 FNH 1 680x512px.tif|Reticulin shows regeneration [two nuclei thick cords between black lines] (400X)]] | |||
|} | |||
Focal nodular hyperplasia. Trichrome shows fibrous scar with vessels/bile ductules (UL 40X). PAS-D shows tortuous bile ductules at edge of scar with minimal inflammation (UR 200X). | |||
PAS-D shows proliferated blood vessels in center of scar with minimal inflammation (LL 200X). Reticulin shows regeneration [two nuclei thick cords between black lines] (LR 400X). | |||
==See also== | ==See also== | ||