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Difference between revisions of "Basal crypt dysplasia"
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*Molecular changes in the crypt base can be identified in the surface cells.<ref name=pmid23695891/> | *Molecular changes in the crypt base can be identified in the surface cells.<ref name=pmid23695891/> | ||
*Strong association with conventional dysplasia/adenocarcinoma. | *Strong association with conventional dysplasia/adenocarcinoma. | ||
**In one series, 87% of individual with BCD had dysplasia ''or'' adenocarcinoma in other tissue samples.<ref name=pmid16625087/> | **In one series, 87% of individual with BCD had [[columnar dysplasia of the esophagus|columnar dysplasia]] ''or'' [[esophageal adenocarcinoma|adenocarcinoma]] in other tissue samples.<ref name=pmid16625087/> | ||
*Reproducibility among pathologists is worse than [[columnar dysplasia of the esophagus|high-grade dysplasia]] but better than low-grade dysplasia.<ref name=pmid21970480/> | *Reproducibility among pathologists is worse than [[columnar dysplasia of the esophagus|high-grade dysplasia]] but better than low-grade dysplasia.<ref name=pmid21970480/> | ||
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**Nuclear crowding (pseudostratification). | **Nuclear crowding (pseudostratification). | ||
*Non-dysplastic (normal) surface epithelium.<ref name=pmid23695891/> | *Non-dysplastic (normal) surface epithelium.<ref name=pmid23695891/> | ||
DDx: | |||
*Indefinite for [[columnar dysplasia of the esophagus]]. | |||
*[[Columnar dysplasia of the esophagus]]. | |||
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* | *Cut levels to look for a definite lesion. | ||
*Probably best to avoid; call it "indefinite for dysplasia". | |||
Note: | |||
*Voltaggio ''et al.'' advocate it should be treated like low-grade dysplasia (requires a follow-up biopsy).<ref name=pmid21970480/> | *Voltaggio ''et al.'' advocate it should be treated like low-grade dysplasia (requires a follow-up biopsy).<ref name=pmid21970480/> | ||