Difference between revisions of "Klinefelter syndrome"
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==Prevalence== | ==Prevalence== | ||
*1 in 500.<ref name=pmid20348547>{{Cite journal | last1 = Vignozzi | first1 = L. | last2 = Corona | first2 = G. | last3 = Forti | first3 = G. | last4 = Jannini | first4 = EA. | last5 = Maggi | first5 = M. | title = Clinical and therapeutic aspects of Klinefelter's syndrome: sexual function. | journal = Mol Hum Reprod | volume = 16 | issue = 6 | pages = 418-24 | month = Jun | year = 2010 | doi = 10.1093/molehr/gaq022 | PMID = 20348547 }}</ref> | *1 in 500 males.<ref name=pmid20348547>{{Cite journal | last1 = Vignozzi | first1 = L. | last2 = Corona | first2 = G. | last3 = Forti | first3 = G. | last4 = Jannini | first4 = EA. | last5 = Maggi | first5 = M. | title = Clinical and therapeutic aspects of Klinefelter's syndrome: sexual function. | journal = Mol Hum Reprod | volume = 16 | issue = 6 | pages = 418-24 | month = Jun | year = 2010 | doi = 10.1093/molehr/gaq022 | PMID = 20348547 }}</ref> | ||
==Characteristics== | ==Characteristics== | ||
Mnemonic ''Mr KLINE FELT Some Guys'':<ref>URL: [http://www.lifehugger.com/moc/2840/Klinefelters_syndrome_KS http://www.lifehugger.com/moc/2840/Klinefelters_syndrome_KS]. Accessed on: 27 March 2012.</ref> | Mnemonic ''Mr KLINE FELT Some Guys'':<ref>URL: [http://www.lifehugger.com/moc/2840/Klinefelters_syndrome_KS http://www.lifehugger.com/moc/2840/Klinefelters_syndrome_KS]. Accessed on: 27 March 2012.</ref> | ||
*'''M'''ale phenotype. | *'''M'''ale phenotype. | ||
*'''K'''aryotype usu. 47 | *'''K'''aryotype usu. 47 XXY. | ||
*'''L'''ong/tall. | *'''L'''ong/tall. | ||
*'''I'''nfertile. | *'''I'''nfertile. | ||
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*'''F'''SH elevated, minimal '''F'''acial & axillary hair. | *'''F'''SH elevated, minimal '''F'''acial & axillary hair. | ||
*'''E'''stradiol/testosterone ratio elevation. | *'''E'''stradiol/testosterone ratio elevation. | ||
*'''L'''H elevated, [[ | *'''L'''H elevated, [[leukemia|'''L'''eukemias]] risk increase ([[AML]]), '''L'''earning disability. | ||
*'''T'''estosterone low. | *'''T'''estosterone low. | ||
*'''S'''mall [[penis]] & [[testis]]. | *'''S'''mall [[penis]] & [[testis]]. | ||
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==See also== | ==See also== | ||
*[[Chromosomal anomalies]]. | *[[Chromosomal anomalies]]. | ||
*[[Leydig cell hyperplasia]]. | |||
==References== | ==References== | ||
Latest revision as of 11:36, 25 June 2016
Klinefelter syndrome, abbreviated KS, is a common genetic abnormality in men.
Prevalence
- 1 in 500 males.[1]
Characteristics
Mnemonic Mr KLINE FELT Some Guys:[2]
- Male phenotype.
- Karyotype usu. 47 XXY.
- Long/tall.
- Infertile.
- Nondisjunction of sex chromosomes.
- Eunuchoid body proportions.
- FSH elevated, minimal Facial & axillary hair.
- Estradiol/testosterone ratio elevation.
- LH elevated, Leukemias risk increase (AML), Learning disability.
- Testosterone low.
- Small penis & testis.
- Gynecomastia.
See also
References
- ↑ Vignozzi, L.; Corona, G.; Forti, G.; Jannini, EA.; Maggi, M. (Jun 2010). "Clinical and therapeutic aspects of Klinefelter's syndrome: sexual function.". Mol Hum Reprod 16 (6): 418-24. doi:10.1093/molehr/gaq022. PMID 20348547.
- ↑ URL: http://www.lifehugger.com/moc/2840/Klinefelters_syndrome_KS. Accessed on: 27 March 2012.