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Difference between revisions of "Papillary adenoma of the kidney"
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Papillary adenoma of the kidney (view source)
Revision as of 12:57, 23 June 2016
, 12:57, 23 June 2016→General
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| Caption = Papillary adenoma. [[H&E stain]]. | | Caption = Papillary adenoma. [[H&E stain]]. | ||
| Synonyms = papillary adenoma, renal papillary adenoma | | Synonyms = papillary adenoma, renal papillary adenoma | ||
| Micro = papillae typically with foam cells, +/-psammoma bodies, | | Micro = papillae typically with foam cells, +/-psammoma bodies, low [[ISUP nucleolar grade]], ''must'' be <=1.5 cm | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[papillary renal cell carcinoma]], [[metanephric adenoma]] | | LMDDx = [[papillary renal cell carcinoma]], [[metanephric adenoma]] | ||
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**Stains like PaRCC. | **Stains like PaRCC. | ||
**Found with an increased frequency within the content of PaRCC. | **Found with an increased frequency within the content of PaRCC. | ||
Note: | |||
*In the kidney, the concept of ''[[adenoma]]'' only exists for papillary lesions that are [[papillary RCC]]-like. Small lesions that are [[chromophobe RCC]]-like or [[clear cell RCC]]-like are carcinomas.<ref name=pmid18846240/> | |||
==Gross== | ==Gross== | ||
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Features: | Features: | ||
#Histomorphology of ''[[papillary renal cell carcinoma]]'' with low [[ISUP nucleolar grade]] (grade 1 or 2). | #Histomorphology of ''[[papillary renal cell carcinoma]]'' with low [[ISUP nucleolar grade]] (grade 1 or 2). | ||
# | #''Must'' be <=1.5 cm as per 2016 WHO classification.<ref name=pmid26935559>{{Cite journal | last1 = Moch | first1 = H. | last2 = Cubilla | first2 = AL. | last3 = Humphrey | first3 = PA. | last4 = Reuter | first4 = VE. | last5 = Ulbright | first5 = TM. | title = The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. | journal = Eur Urol | volume = | issue = | pages = | month = Feb | year = 2016 | doi = 10.1016/j.eururo.2016.02.029 | PMID = 26935559 }}</ref> | ||
#*[[Diagnostic size cutoff]] - larger lesions are ''papillary renal cell carcinoma''. | #*[[Diagnostic size cutoff]] - larger lesions are ''papillary renal cell carcinoma''. | ||
Note: | |||
*The size cut-off used to be <=0.5 cm.<ref name=pmid26935559/><ref name=Ref_GUP288>{{Ref GUP|288}}</ref><ref name=pmid18846240>{{Cite journal | last1 = Algaba | first1 = F. | title = Renal adenomas: pathological differential diagnosis with malignant tumors. | journal = Adv Urol | volume = | issue = | pages = 974848 | month = | year = 2008 | doi = 10.1155/2008/974848 | PMID = 18846240 | PMC = 2563151 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563151/?tool=pubmed }}</ref> | |||
DDx: | DDx: | ||
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*[[Metanephric adenoma]]. | *[[Metanephric adenoma]]. | ||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
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==IHC== | ==IHC== | ||
*CK7 +ve. | |||
*AMACR +ve.<ref name=pmid17056094/> | *AMACR +ve.<ref name=pmid17056094/> | ||