Difference between revisions of "Steatohepatitis"

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Steatohepatitis (view source)

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→‎Grading steatohepatitis
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===Grading steatohepatitis===
===Grading steatohepatitis===
Grading inflammation:<ref name=pmid10484010>{{Cite journal  | last1 = Brunt | first1 = EM. | last2 = Janney | first2 = CG. | last3 = Di Bisceglie | first3 = AM. | last4 = Neuschwander-Tetri | first4 = BA. | last5 = Bacon | first5 = BR. | title = Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. | journal = Am J Gastroenterol | volume = 94 | issue = 9 | pages = 2467-74 | month = Sep | year = 1999 | doi = 10.1111/j.1572-0241.1999.01377.x | PMID = 10484010 }}</ref>
====Brunt grading system====
*Grade 1 - steatosis, [[PMN]]s, occasional ballooning degeneration. ‡
Grading system proposed by Brunt in 1999:<ref name=pmid10484010>{{Cite journal  | last1 = Brunt | first1 = EM. | last2 = Janney | first2 = CG. | last3 = Di Bisceglie | first3 = AM. | last4 = Neuschwander-Tetri | first4 = BA. | last5 = Bacon | first5 = BR. | title = Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. | journal = Am J Gastroenterol | volume = 94 | issue = 9 | pages = 2467-74 | month = Sep | year = 1999 | doi = 10.1111/j.1572-0241.1999.01377.x | PMID = 10484010 }}</ref>
*Grade 2 - obvious ballooning, obvious PMNs, chronic inflammation.
{| class="wikitable sortable" style="text-align: center
*Grade 3 - panacinar steatosis.
! Grade
 
! Characteristics
|-
| 1  
| steatosis, [[PMN]]s, occasional ballooning degeneration ‡
|-
| 2  
| obvious ballooning, obvious PMNs, chronic inflammation
|-
| 3  
| panacinar steatosis
|}
Note:
Note:
*‡ Ballooning may be absent.<ref name=pmid10484010/>  
*‡ Ballooning may be absent.<ref name=pmid10484010/>  
====Clinical Research Network system====
Nonalcoholic steatohepatitis Clinical Research Network system for scoring activity - adapted from Brunt and Tiniakos:<ref name=pmid21072891>{{Cite journal  | last1 = Brunt | first1 = EM. | last2 = Tiniakos | first2 = DG. | title = Histopathology of nonalcoholic fatty liver disease. | journal = World J Gastroenterol | volume = 16 | issue = 42 | pages = 5286-96 | month = Nov | year = 2010 | doi =  | PMID = 21072891 }}</ref>
{| class="wikitable sortable" style="text-align: center
! Score
! Steatotic <br>hepatocytes (%)
! Lobular <br>lymphocytes
! Ballooning <br>heptocytes
|-
| 0
| <5%
| none
| none
|-
| 1
| 5-33%
| <2
| few
|-
| 2
| 34%-66%
| 2-4
| many
|-
| 3
| >66%
| >4
| (not assigned)
|}


====Images====
====Images====
Michael
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