Difference between revisions of "Hemolytic uremic syndrome"

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*''E. coli'' serotype O157:H7.
*''E. coli'' serotype O157:H7.
**Verotoxins from ''E. coli'' O157:H7 --> endothelial injury.<ref name=pmid19180125>{{cite journal |author=Petruzziello TN, Mawji IA, Khan M, Marsden PA |title=Verotoxin biology: molecular events in vascular endothelial injury |journal=Kidney Int. Suppl. |volume= |issue=112 |pages=S17–9 |year=2009 |month=February |pmid=19180125 |doi=10.1038/ki.2008.612 |url=}}</ref>
**Verotoxins from ''E. coli'' O157:H7 --> endothelial injury.<ref name=pmid19180125>{{cite journal |author=Petruzziello TN, Mawji IA, Khan M, Marsden PA |title=Verotoxin biology: molecular events in vascular endothelial injury |journal=Kidney Int. Suppl. |volume= |issue=112 |pages=S17–9 |year=2009 |month=February |pmid=19180125 |doi=10.1038/ki.2008.612 |url=}}</ref>
==Pathology==
In children partial omentectomies are done in the placement of peritoneal catheters (for dialysis), to avoid subsequent blockage.<ref name=pmid7838254>{{cite journal |author=Pumford N, Cassey J, Uttley WS |title=Omentectomy with peritoneal catheter placement in acute renal failure |journal=Nephron |volume=68 |issue=3 |pages=327–8 |year=1994 |pmid=7838254 |doi= |url=}}</ref>
===Microscopic===
Features:
*Mesothelial-lined fibroadipose tissue.


==Relation to [[thrombotic thrombocytopenic purpura]] (TTP)==
==Relation to [[thrombotic thrombocytopenic purpura]] (TTP)==

Revision as of 19:07, 16 March 2011

Hemolytic uremic syndrome, abbreviated HUS, is the triad of:[1]

  • Microangiopathic hemolytic anemia.
    • Microangiopathic = disease affecting small blood vessels.[2]
  • Thrombocytopenia = low platelet count.
  • Acute renal failure.

Etiology

  • Rare (uncooked) hamburger.
  • E. coli serotype O157:H7.
    • Verotoxins from E. coli O157:H7 --> endothelial injury.[3]

Pathology

In children partial omentectomies are done in the placement of peritoneal catheters (for dialysis), to avoid subsequent blockage.[4]

Microscopic

Features:

  • Mesothelial-lined fibroadipose tissue.

Relation to thrombotic thrombocytopenic purpura (TTP)

  • TTP is the main (clinical) DDx of HUS.
    • It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
  • Both are classified as thrombotic microangiopathies.[5]

See also

References

  1. URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
  2. URL: http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm. Accessed on: 9 September 2010.
  3. Petruzziello TN, Mawji IA, Khan M, Marsden PA (February 2009). "Verotoxin biology: molecular events in vascular endothelial injury". Kidney Int. Suppl. (112): S17–9. doi:10.1038/ki.2008.612. PMID 19180125.
  4. Pumford N, Cassey J, Uttley WS (1994). "Omentectomy with peritoneal catheter placement in acute renal failure". Nephron 68 (3): 327–8. PMID 7838254.
  5. URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.