Difference between revisions of "Parathyroid carcinoma"
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'''Parathyroid carcinoma''' is a rare epithelial malignancy of the [[parathyroid gland]]. | |||
==General== | |||
*Extremely rare. | |||
==Microscopic== | |||
Features:<ref>{{Ref PBoD8|1128}}</ref> | |||
*Histologically normal parathyroid cells. | |||
**Cytologic features '''not''' reliable for diagnosis. | |||
*Fibrous capsule. | |||
*Invasion of surrounding tissue - '''key feature'''. | |||
*+/-[[Metastasis]] - '''diagnostic feature'''. | |||
Note: | |||
*Diagnosis of ''parathyroid carcinoma'' is like that of ''malignant [[pheochromocytoma]]'' - cytology useless, tissue invasion and metastases are the key features. | |||
===Images=== | |||
*[http://emedicine.medscape.com/article/280908-overview Parathyroid carcinoma (medscape.com)]. | |||
==IHC== | |||
*Ki-67 >6% of cells positive - supports diagnosis.<ref name=pmid7860042>{{Cite journal | last1 = Abbona | first1 = GC. | last2 = Papotti | first2 = M. | last3 = Gasparri | first3 = G. | last4 = Bussolati | first4 = G. | title = Proliferative activity in parathyroid tumors as detected by Ki-67 immunostaining. | journal = Hum Pathol | volume = 26 | issue = 2 | pages = 135-8 | month = Feb | year = 1995 | doi = | PMID = 7860042 }}</ref> | |||
**Parathyroid adenomas and hyperplasias ~ 3%. | |||
==See also== | |||
*[[Parathyroid gland]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Endocrine pathology]] | |||
Revision as of 03:56, 7 June 2016
Parathyroid carcinoma is a rare epithelial malignancy of the parathyroid gland.
General
- Extremely rare.
Microscopic
Features:[1]
- Histologically normal parathyroid cells.
- Cytologic features not reliable for diagnosis.
- Fibrous capsule.
- Invasion of surrounding tissue - key feature.
- +/-Metastasis - diagnostic feature.
Note:
- Diagnosis of parathyroid carcinoma is like that of malignant pheochromocytoma - cytology useless, tissue invasion and metastases are the key features.
Images
IHC
- Ki-67 >6% of cells positive - supports diagnosis.[2]
- Parathyroid adenomas and hyperplasias ~ 3%.
See also
References
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1128. ISBN 978-1416031215.
- ↑ Abbona, GC.; Papotti, M.; Gasparri, G.; Bussolati, G. (Feb 1995). "Proliferative activity in parathyroid tumors as detected by Ki-67 immunostaining.". Hum Pathol 26 (2): 135-8. PMID 7860042.