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Difference between revisions of "Diagnostic size cutoffs"
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[[Image:Lung carcinoid tumourlet - low mag.jpg|thumb|right|A [[carcinoid tumourlet]]; if it were larger it would be a [[carcinoid lung tumour]]. [[H&E stain]].]] | |||
'''Diagnostic size cutoffs''' are cutoffs which (in part) define a [[diagnosis]] and are seen in a number of places in [[pathology]]. They are usually somewhat arbitrary by their nature; however, they often make sense from a biologic big picture/management perspective. It doesn't make sense to treat [[ADH]] and low-grade [[DCIS]] the same, as their behaviour is different. | '''Diagnostic size cutoffs''' are cutoffs which (in part) define a [[diagnosis]] and are seen in a number of places in [[pathology]]. They are usually somewhat arbitrary by their nature; however, they often make sense from a biologic big picture/management perspective. It doesn't make sense to treat [[ADH]] and low-grade [[DCIS]] the same, as their behaviour is different. | ||
In [[pathology]], size matters. With other things equal, in the context of how tumours are currently evaluated, big tumours do worse than small tumours. | ==Rationale== | ||
In [[pathology]], size matters. With other things equal, in the context of how tumours are currently evaluated, big tumours usually do worse than small tumours. | |||
==A table of diagnostic size cutoffs== | |||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
! | !Smaller lesion (precursor) | ||
!Cutoff | !Cutoff value (smaller lesion) | ||
! | !Larger lesion (cancer) | ||
!Notes | !Notes | ||
|- | |- | ||
|[[Papillary adenoma of the kidney]] | |[[Papillary adenoma of the kidney]] | ||
|<= | |<=1.5 cm<ref name=pmid26935559>{{Cite journal | last1 = Moch | first1 = H. | last2 = Cubilla | first2 = AL. | last3 = Humphrey | first3 = PA. | last4 = Reuter | first4 = VE. | last5 = Ulbright | first5 = TM. | title = The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. | journal = Eur Urol | volume = | issue = | pages = | month = Feb | year = 2016 | doi = 10.1016/j.eururo.2016.02.029 | PMID = 26935559 }}</ref> | ||
|[[Papillary renal cell carcinoma]] | |[[Papillary renal cell carcinoma]] | ||
| - | | must be low [[ISUP nucleolar grade]] to call ''papillary adenoma''; cut-off was 0.5 cm in previous WHO GU book<ref>{{Ref WHOGU|28}}</ref> | ||
|- | |- | ||
|[[Atypical alveolar hyperplasia]] | | [[Atypical alveolar hyperplasia]] | ||
|<5 mm<ref name=Ref_WMSP114>{{Ref WMSP|114}}</ref> | | <5 mm<ref name=Ref_WMSP114>{{Ref WMSP|114}}</ref> | ||
|Adenocarcinoma in situ of the lung | | Adenocarcinoma in situ of the lung | ||
| - | | - | ||
|- | |- | ||
|[[Atypical ductal hyperplasia]] | | [[Atypical ductal hyperplasia]] | ||
|<2mm | | <2mm | ||
|Low-grade [[ductal carcinoma in situ]] | | Low-grade [[ductal carcinoma in situ]] | ||
| Different criterion for lesions in an [[intraductal papilloma]] | | Different criterion for lesions in an [[intraductal papilloma of the breast]] | ||
|- | |- | ||
|[[Atypical ductal hyperplasia]] in an [[intraductal papilloma]] | | [[Atypical ductal hyperplasia]] in an [[intraductal papilloma of the breast]] | ||
|<3mm | | <3mm | ||
|Low-grade [[ductal carcinoma in situ]] in an intraductal papilloma | | Low-grade [[ductal carcinoma in situ]] in an intraductal papilloma | ||
| Different criterion for lesions '''not''' in an [[intraductal papilloma of the breast]] | |||
|- | |- | ||
| [[Pulmonary carcinoid tumourlet]] | | [[Pulmonary carcinoid tumourlet]] | ||
| < | | <5 mm<ref name=pct_ucsf>URL: [http://pathhsw5m54.ucsf.edu/case7/image75.html http://pathhsw5m54.ucsf.edu/case7/image75.html]. Accessed on: 23 January 2012.</ref><ref name=pmid23205296>{{Cite journal | last1 = He | first1 = P. | last2 = Gu | first2 = X. | last3 = Wu | first3 = Q. | last4 = Lin | first4 = Y. | last5 = Gu | first5 = Y. | last6 = He | first6 = J. | title = Pulmonary carcinoid tumorlet without underlying lung disease: analysis of its relationship to fibrosis. | journal = J Thorac Dis | volume = 4 | issue = 6 | pages = 655-8 | month = Dec | year = 2012 | doi = 10.3978/j.issn.2072-1439.2012.06.11 | PMID = 23205296 }}</ref> | ||
| [[Typical carcinoid lung tumour]] | | [[Typical carcinoid lung tumour]] | ||
| ''Typical carcinoid lung tumour'' '''not''' a cancer | | ''Typical carcinoid lung tumour'' '''not''' a cancer | ||
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*[[Diagnosis]]. | *[[Diagnosis]]. | ||
*[[Cancer]]. | *[[Cancer]]. | ||
*[[Cancer staging systems]]. | |||
==References== | ==References== | ||
{{Reflist|1}} | {{Reflist|1}} | ||
[[Category: | [[Category:Cancer staging]] | ||