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Difference between revisions of "Flat epithelial atypia"
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'''Flat epithelial atypia''', abbreviated '''FEA''', is a benign breast lesion that is associated with an increased risk of subsequent [[breast cancer]]. | |||
==General== | |||
Epidemiology: | |||
*Associated with [[ADH]] & [[DCIS]]; may represent a non-obligate precursor lesion of ADH & DCIS.<ref name=pmid18384213>{{Cite journal | last1 = Lerwill | first1 = MF. | title = Flat epithelial atypia of the breast. | journal = Arch Pathol Lab Med | volume = 132 | issue = 4 | pages = 615-21 | month = Apr | year = 2008 | doi = 10.1043/1543-2165(2008)132[615:FEAOTB]2.0.CO;2 | PMID = 18384213 }}</ref> | |||
*Low risk of progression to invasive malignancy.<ref name=pmid12927037>{{Cite journal | last1 = Schnitt | first1 = SJ. | title = The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance. | journal = Breast Cancer Res | volume = 5 | issue = 5 | pages = 263-8 | month = | year = 2003 | doi = 10.1186/bcr625 | PMID = 12927037 }}</ref> | |||
Management: | |||
*Excision. | |||
==Microscopic== | |||
Features: | |||
*"Flat" ~ three cells thick. | |||
*Hypercellular gland -- several layers. | |||
*Columnar cell morphology. | |||
*+/-Apical snouts. | |||
DDx: | |||
*[[Columnar cell change]]. | |||
*Columnar cell hyperplasia. | |||
*[[ADH]]. | |||
*Flat [[DCIS]] (clinging carcinoma). | |||
*Apocrine cyst - granular cytoplasm. | |||
*[[Tubular carcinoma]] - should be considered due to the association. | |||
==Images== | |||
<gallery> | |||
Image:Breast FlatAtypia (3) PA.JPG|Breast - Flat Atypia (SKB) | |||
</gallery> | |||
==Molecular== | |||
*Loss of 16q. | |||
**Not used for [[diagnosis]]. | |||
==See also== | |||
*[[Breast pathology]]. | |||
*[[Atypical ductal hyperplasia]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Breast pathology]] | |||