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Difference between revisions of "Small round cell tumours"
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| [[Hepatoblastoma]] | | [[Hepatoblastoma]] | ||
| fetal hepatocytes (~ 1:3 NC ratio, eosinophilic cytoplasm) | | fetal hepatocytes (~ 1:3 NC ratio, '''eosinophilic cytoplasm''') | ||
| liver lesion, usu. < 3 years old | | liver lesion, usu. < 3 years old | ||
| AFP | | AFP | ||
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| [[Alveolar rhabdomyosarcoma]] | | [[Alveolar rhabdomyosarcoma]] | ||
| rhabdomyocytes (eosinophilic cytoplasm +/-cross striations (uncommon), eccentric nucleus) | | '''alveolar-like spaces''' (small blue cells line spaces supported by fibrous tissue) rhabdomyocytes (eosinophilic cytoplasm +/-cross striations (uncommon), eccentric nucleus) | ||
| adolescents, young adults; often mets at presentation | | adolescents, young adults; often mets at presentation | ||
| "DAM" = desmin, actin, myogenin | | "DAM" = desmin, actin, myogenin | ||
|- | |- | ||
| [[Embryonal rhabdomyosarcoma]]<sup>§</sup> | | [[Embryonal rhabdomyosarcoma]]<sup>§</sup> | ||
| rhabdomyocytes (elongated/cigar-shaped cells, eosinophilic cytoplasm +/-cross striations, eccentric nucleus), nests with rounded border | | rhabdomyocytes (elongated/cigar-shaped cells, eosinophilic cytoplasm +/-cross striations, eccentric nucleus), '''nests with rounded border''' | ||
| <10 years old; usu. localized | | <10 years old; usu. localized | ||
| "DAM" = desmin, actin, myogenin | | "DAM" = desmin, actin, myogenin | ||
|- | |- | ||
| [[Desmoplastic small round cell tumour]] (DSRCT) | | [[Desmoplastic small round cell tumour]] (DSRCT) | ||
| nests with "jigsaw" border | | '''nests with "jigsaw" border''' | ||
| peritoneum (abdomen or plevis); male > female; locally invasive | | peritoneum (abdomen or plevis); male > female; locally invasive | ||
| keratin+, EMA+, desmin+ !!! | | keratin+, EMA+, desmin+ !!! | ||
|- | |- | ||
| Small cell carcinoma | | Small cell carcinoma | ||
| stippled chromatin, nuclear moulding | | stippled chromatin, '''nuclear moulding''' | ||
| adults, smokers | | adults, smokers | ||
| synaptophysin, chromogranin, CD56, keratins | | synaptophysin, chromogranin, CD56, keratins | ||
|- | |- | ||
| [[Lymphoma]], non-Hogkin's, usu. large cell | | [[Lymphoma]], non-Hogkin's, usu. large cell (e.g. [[DLBCL]]) | ||
| dyscohesive cells, usu. ~2x normal (resting) lymphocyte, usu. nucleolus | | dyscohesive cells, usu. ~2x normal (resting) lymphocyte, usu. nucleolus | ||
| lymphadenopathy (???) | | lymphadenopathy (???) | ||