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Difference between revisions of "Asbestosis"
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Asbestosis is [[diffuse lung disease]] due to asbestos exposure. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Asbestosis_high_mag.jpg | |||
| Width = | |||
| Caption = Asbestosis. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = interstitial fibrosis (similar to [[usual interstitial pneumonia]]), ferruginous bodies (segmented twirling baton with long slender fibre within it) | |||
| Subtypes = | |||
| LMDDx = [[usual interstitial pneumonia]] | |||
| Stains = [[Iron stain]] +ve (ferruginous bodies) | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lung]] - see ''[[diffuse lung diseases]]'' | |||
| Assdx = [[pleural plaques]], [[pleural effusion]] (may be benign), [[malignant mesothelioma]] | |||
| Syndromes = | |||
| Clinicalhx = exposure to asbestos | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = interstitial pattern, lower lobe predominant | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Asbestosis''' is a [[diffuse lung disease]] due to asbestos exposure. It is a type of [[hypersensitivity pneumonitis]].<ref name=pmid21978856>{{cite journal |author=Zacharisen MC, Fink JN |title=Hypersensitivity pneumonitis and related conditions in the work environment |journal=Immunol Allergy Clin North Am |volume=31 |issue=4 |pages=769–86, vii |year=2011 |month=November |pmid=21978856 |doi=10.1016/j.iac.2011.07.004 |url=}}</ref> | |||
==General== | ==General== | ||
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Diagnosis: | Diagnosis: | ||
*Rests on morphology with special techniques (e.g. polarization)<ref>{{Cite journal | last1 = Galateau-Salle | first1 = F. | title = [Anatomopathological tools for screening and medical surveillance of people exposed to asbestos]. | journal = Rev Mal Respir | volume = 16 | issue = 6 Pt 2 | pages = 1244-56 | month = Dec | year = 1999 | doi = | PMID = 10897845 }}</ref> and includes tunneling [[electron microscopy]] (TEM),<ref name=pmid21479897>{{Cite journal | last1 = Neumann | first1 = V. | last2 = Löseke | first2 = S. | last3 = Tannapfel | first3 = A. | title = Mesothelioma and analysis of tissue fiber content. | journal = Recent Results Cancer Res | volume = 189 | issue = | pages = 79-95 | month = | year = 2011 | doi = 10.1007/978-3-642-10862-4_6 | PMID = 21479897 }}</ref> as done at special centres. | *Rests on morphology with special techniques (e.g. [[polarization]])<ref name=pmid10897845>{{Cite journal | last1 = Galateau-Salle | first1 = F. | title = [Anatomopathological tools for screening and medical surveillance of people exposed to asbestos]. | journal = Rev Mal Respir | volume = 16 | issue = 6 Pt 2 | pages = 1244-56 | month = Dec | year = 1999 | doi = | PMID = 10897845 }}</ref> and includes tunneling [[electron microscopy]] (TEM),<ref name=pmid21479897>{{Cite journal | last1 = Neumann | first1 = V. | last2 = Löseke | first2 = S. | last3 = Tannapfel | first3 = A. | title = Mesothelioma and analysis of tissue fiber content. | journal = Recent Results Cancer Res | volume = 189 | issue = | pages = 79-95 | month = | year = 2011 | doi = 10.1007/978-3-642-10862-4_6 | PMID = 21479897 }}</ref> as done at special centres. | ||
**Tissue is typically digested prior to fibre counting.<ref name=pmid20196674>{{Cite journal | last1 = Roggli | first1 = VL. | last2 = Gibbs | first2 = AR. | last3 = Attanoos | first3 = R. | last4 = Churg | first4 = A. | last5 = Popper | first5 = H. | last6 = Cagle | first6 = P. | last7 = Corrin | first7 = B. | last8 = Franks | first8 = TJ. | last9 = Galateau-Salle | first9 = F. | title = Pathology of asbestosis- An update of the diagnostic criteria: Report of the asbestosis committee of the college of american pathologists and pulmonary pathology society. | journal = Arch Pathol Lab Med | volume = 134 | issue = 3 | pages = 462-80 | month = Mar | year = 2010 | doi = 10.1043/1543-2165-134.3.462 | PMID = 20196674 }}</ref> | **Tissue is typically digested prior to fibre counting.<ref name=pmid20196674>{{Cite journal | last1 = Roggli | first1 = VL. | last2 = Gibbs | first2 = AR. | last3 = Attanoos | first3 = R. | last4 = Churg | first4 = A. | last5 = Popper | first5 = H. | last6 = Cagle | first6 = P. | last7 = Corrin | first7 = B. | last8 = Franks | first8 = TJ. | last9 = Galateau-Salle | first9 = F. | title = Pathology of asbestosis- An update of the diagnostic criteria: Report of the asbestosis committee of the college of american pathologists and pulmonary pathology society. | journal = Arch Pathol Lab Med | volume = 134 | issue = 3 | pages = 462-80 | month = Mar | year = 2010 | doi = 10.1043/1543-2165-134.3.462 | PMID = 20196674 }}</ref> | ||
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Features:<ref name=pmid20196674/> | Features:<ref name=pmid20196674/> | ||
#Interstitial fibrosis - similar to [[usual interstitial pneumonia]] (UIP). | #Interstitial fibrosis - similar to [[usual interstitial pneumonia]] (UIP). | ||
#''Ferruginous bodies'' - '''key feature'''. | #''[[Ferruginous bodies]]'' - '''key feature'''. | ||
#*Segmented twirling baton with long slender fibre within. | #*Segmented twirling baton with long slender fibre within. | ||
#*Black crystal-like appearance - may be confused with dirt on H&E. | |||
===Images=== | ===Images=== | ||
| Line 29: | Line 61: | ||
Image:Ferruginous_body.jpg | Ferruginous bodies. (WC) | Image:Ferruginous_body.jpg | Ferruginous bodies. (WC) | ||
Image:Asbestosis_high_mag.jpg | Asbestosis. (WC) | Image:Asbestosis_high_mag.jpg | Asbestosis. (WC) | ||
Image:Carcinoma asbestos body lung.jpg | Ferruginous body in carcinoma - cytology. (WC/Alex Brollo) | |||
</gallery> | </gallery> | ||
==Stains== | |||
*[[Iron stain]] +ve. | |||
==See also== | ==See also== | ||