Graves' disease: Difference between revisions
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| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = "beefy-red" appearance, enlarged | | Gross = "beefy-red" appearance, enlarged, +/-white nodules | ||
| Grossing = | | Grossing = | ||
| Staging = | | Staging = | ||
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| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = exophthalmos | | Signs = exophthalmos, signs of hyperthyroidism (tremor, muscle wasting, weight loss, tachycardia, sweating) | ||
| Symptoms = | | Symptoms = symptoms of hyperthyroidism (palpitations, fatigue, restlessness, oligomenorrhea, amenorrhea, intolerance to heart, diarrhea, irritability) | ||
| Prevalence = uncommon | | Prevalence = uncommon | ||
| Bloodwork = TSH-receptor antibody - required | | Bloodwork = TSH-receptor antibody - required | ||
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==Gross== | ==Gross== | ||
Features:<ref>{{Ref EP|30}}</ref> | Features: | ||
*Enlarged 50-150 g. | *Classic appearance:<ref name=Ref_EP30>{{Ref EP|30}}</ref> | ||
*"Beefy-red" appearance, looks like raw beef. | **Enlarged 50-150 g. | ||
**"Beefy-red" appearance, looks like raw beef. | |||
*May have scattered white nodules (lymphocytes). | |||
==Microscopic== | ==Microscopic== | ||
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*Classic: | *Classic: | ||
**Hypercellular | **Hypercellular | ||
**Patchy lymphocytes. | **Patchy lymphocytes.<ref name=pmid6129766>{{Cite journal | last1 = Leövey | first1 = A. | last2 = Bakó | first2 = G. | last3 = Sztojka | first3 = I. | last4 = Bordán | first4 = L. | last5 = Szabó | first5 = T. | last6 = Kálmán | first6 = K. | last7 = Balázs | first7 = C. | title = The pathogenetic connection between Graves' disease and chronic lymphocytic thyroiditis. (The role and incidence of thyroid stimulating antibodies). | journal = Acta Med Acad Sci Hung | volume = 39 | issue = 1-2 | pages = 1-6 | month = | year = 1982 | doi = | PMID = 6129766 }}</ref> | ||
**Little colloid. | **Little colloid. | ||
*Scalloping of colloid; colloid has undulating border. | *Scalloping of colloid; colloid has undulating border. | ||
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DDx: | DDx: | ||
*[[Papillary thyroid carcinoma]]. | *[[Papillary thyroid carcinoma]]. | ||
*[[Lymphocytic thyroiditis]]. | |||
===Images=== | ===Images=== | ||
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*[http://library.med.utah.edu/WebPath/jpeg4/ENDO022.jpg Graves' disease (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html]. Accessed on: 4 December 2011.</ref> | *[http://library.med.utah.edu/WebPath/jpeg4/ENDO022.jpg Graves' disease (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html]. Accessed on: 4 December 2011.</ref> | ||
*[http://medcell.med.yale.edu/histology/endocrine_systems_lab/graves_disease.php Graves' disease & normal thyroid (yale.edu)]. | *[http://medcell.med.yale.edu/histology/endocrine_systems_lab/graves_disease.php Graves' disease & normal thyroid (yale.edu)]. | ||
==Sign out== | |||
===History provided=== | |||
<pre> | |||
Total Thyroid, Total Thyroidectomy: | |||
- Lymphocytic thyroiditis compatible with Graves' disease. | |||
- One benign lymph node (0/1). | |||
- NEGATIVE for malignancy. | |||
</pre> | |||
==See also== | ==See also== | ||