Difference between revisions of "Oncocytoma of the salivary gland"
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==EM== | ==EM== | ||
*Increased numbers of mitochondria. | *Increased numbers of mitochondria. | ||
==Sign out== | |||
<pre> | |||
Nodule, Right Parotid Gland, Core Biopsy: | |||
- ONCOCYTOMA. | |||
Comment: | |||
The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is not appreciated. | |||
The cells in the biopsy stain as follows: | |||
POSITIVE: p63 (focal, nuclear). | |||
NEGATIVE: CD10, RCC, S-100, CD68, vimentin. | |||
</pre> | |||
==See also== | ==See also== |
Revision as of 18:33, 11 April 2016
Oncocytoma of the salivary gland | |
---|---|
Diagnosis in short | |
Salivary gland oncocytoma. H&E stain. (WC/Nephron) | |
| |
Synonyms | salivary gland oncocytoma |
| |
LM | abundant eosinophilic cytoplasm; architecture: solid, trabecular or duct-like |
LM DDx | acinic cell carcinoma, metastatic renal cell carcinoma, oncocytic carcinoma, granular cell tumour |
IHC | p63 +ve |
EM | increased numbers of mitochondria |
Site | salivary gland |
| |
Prevalence | very rare |
Radiology | blend with normal salivary gland on T1 postcontrast and fat-saturated T2 MR images |
Prognosis | benign |
Clin. DDx | other salivary gland tumours |
Oncocytoma of the salivary gland (also salivary gland oncocytoma) is a rare benign tumour of the salivary glands.
General
- No risk of malignant transformation.
- Rare ~20 reported in literature.[1]
- Thought to be ~1% of all salivary gland tumours.
- Typical age: 60s-80s.
- Associated with radiation exposure.
- Major salivary glands - usually parotid gland.[2]
Gross
- Golden brown appearance.
Note:
- "Disappear" into background salivary gland on MRI: isointense to normal on fat-saturated T2 and T1 postcontrast images.[3]
Image
Microscopic
Features:
- Like oncocytomas elsewhere.
- Abundant eosinophilic cytoplasm (on H&E stain).
- Due to increased number of mitochrondria.
- Fine capillaries.
- Abundant eosinophilic cytoplasm (on H&E stain).
- Architecture: solid sheets, trabeculae or duct-like structure.[2]
Notes:
- May have clear cell change.
- Multiple small incidental lesions = oncocytosis - not oncocytoma.
DDx:
- Acinic cell carcinoma.
- Metastatic renal cell carcinoma - esp. chromophobe renal cell carcinoma.
- Oncocytic carcinoma.
- Granular cell tumour.
Images
www:
IHC
EM
- Increased numbers of mitochondria.
Sign out
Nodule, Right Parotid Gland, Core Biopsy: - ONCOCYTOMA. Comment: The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is not appreciated. The cells in the biopsy stain as follows: POSITIVE: p63 (focal, nuclear). NEGATIVE: CD10, RCC, S-100, CD68, vimentin.
See also
References
- ↑ Uzunkulaoğlu H, Yazici H, Can IH, Doğan S, Uzunkulaoğlu T (May 2012). "Bilateral oncocytoma in the parotid gland". J Craniofac Surg 23 (3): e246–7. doi:10.1097/SCS.0b013e31824dfccd. PMID 22627459.
- ↑ 2.0 2.1 Zhou, CX.; Gao, Y. (Dec 2009). "Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study.". Oral Oncol 45 (12): e232-8. doi:10.1016/j.oraloncology.2009.08.004. PMID 19796983.
- ↑ Patel, ND.; van Zante, A.; Eisele, DW.; Harnsberger, HR.; Glastonbury, CM. (Oct 2011). "Oncocytoma: the vanishing parotid mass.". AJNR Am J Neuroradiol 32 (9): 1703-6. doi:10.3174/ajnr.A2569. PMID 21757520.
- ↑ 4.0 4.1 McHugh, JB.; Hoschar, AP.; Dvorakova, M.; Parwani, AV.; Barnes, EL.; Seethala, RR. (Dec 2007). "p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.". Head Neck Pathol 1 (2): 123-31. doi:10.1007/s12105-007-0031-4. PMC 2807526. PMID 20614263. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807526/.
- ↑ Canberk, S.; Onenerk, M.; Sayman, E.; Goret, CC.; Erkan, M.; Atasoy, T.; Kilicoglu, GZ. (2015). "Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature.". Cytojournal 12: 18. doi:10.4103/1742-6413.162774. PMID 26425134.