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Difference between revisions of "Germ cell neoplasia in situ"
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Germ cell neoplasia in situ (view source)
Revision as of 23:10, 15 March 2016
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| Image = Intratubular germ cell neoplasia - 2 - very high mag.jpg | | Image = Intratubular germ cell neoplasia - 2 - very high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = GCNIS (left of image). [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule | | Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule | ||
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*Not all germ cell tumours (GCTs) arise from ''intratubular germ cell neoplasia''. | *Not all germ cell tumours (GCTs) arise from ''intratubular germ cell neoplasia''. | ||
The following testicular GCTs do not arise from | The following testicular GCTs do not arise from GCNIS: | ||
*[[Spermatocytic | *[[Spermatocytic tumour]].<ref name=pmid2837162>{{cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= |url=}}</ref> | ||
*[[Yolk sac tumour]]s (endodermal sinus tumour).<ref>{{cite journal |author=Manivel JC, Simonton S, Wold LE, Dehner LP |title=Absence of intratubular germ cell neoplasia in testicular yolk sac tumors in children. A histochemical and immunohistochemical study |journal=Arch. Pathol. Lab. Med. |volume=112 |issue=6 |pages=641–5 |year=1988 |month=June |pmid=2837162 |doi= |url=}}</ref> | *[[Yolk sac tumour]]s (endodermal sinus tumour).<ref>{{cite journal |author=Manivel JC, Simonton S, Wold LE, Dehner LP |title=Absence of intratubular germ cell neoplasia in testicular yolk sac tumors in children. A histochemical and immunohistochemical study |journal=Arch. Pathol. Lab. Med. |volume=112 |issue=6 |pages=641–5 |year=1988 |month=June |pmid=2837162 |doi= |url=}}</ref> | ||
*Teratoma.{{Fact}} | *Teratoma.{{Fact}} | ||
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====Case 1==== | ====Case 1==== | ||
<gallery> | <gallery> | ||
Image: Intratubular germ cell neoplasia - intermed mag.jpg | ITGCN - intermed. mag. | Image: Intratubular germ cell neoplasia - intermed mag.jpg | GCNIS (ITGCN) - intermed. mag. | ||
Image: Intratubular germ cell neoplasia - high mag.jpg | ITGCN - high mag. | Image: Intratubular germ cell neoplasia - high mag.jpg | GCNIS (ITGCN) - high mag. | ||
Image: Intratubular germ cell neoplasia - very high mag.jpg | ITGCN - very high mag. | Image: Intratubular germ cell neoplasia - very high mag.jpg | GCNIS (ITGCN) - very high mag. | ||
Image: Intratubular germ cell neoplasia - 2 - very high mag.jpg | ITGCN - very high mag. | Image: Intratubular germ cell neoplasia - 2 - very high mag.jpg | GCNIS (ITGCN) - very high mag. | ||
</gallery> | </gallery> | ||
====Case 2==== | ====Case 2==== | ||
<gallery> | <gallery> | ||
Image:Intratubular_germ_cell_neoplasia_high_mag_cropped.jpg | ITGCN - cropped. (WC/Nephron) | Image:Intratubular_germ_cell_neoplasia_high_mag_cropped.jpg | GCNIS (ITGCN) - cropped. (WC/Nephron) | ||
Image:Intratubular_germ_cell_neoplasia_high_mag.jpg | ITGCN. (WC/Nephron) | Image:Intratubular_germ_cell_neoplasia_high_mag.jpg | GCNIS (ITGCN). (WC/Nephron) | ||
</gallery> | </gallery> | ||
====Case 3==== | ====Case 3==== | ||
<gallery> | <gallery> | ||
Image: ITGCN and Sertoli cells only -- intermed mag.jpg | ITGCN & SCO - intermed. mag. | Image: ITGCN and Sertoli cells only -- intermed mag.jpg | GCNIS (ITGCN) & SCO - intermed. mag. | ||
Image: ITGCN and Sertoli cells only -- high mag.jpg | ITGCN & SCO - high mag. | Image: ITGCN and Sertoli cells only -- high mag.jpg | GCNIS (ITGCN) & SCO - high mag. | ||
Image: ITGCN and Sertoli cells only - PLAP -- intermed mag.jpg | ITGCN & SCO - intermed. mag. | Image: ITGCN and Sertoli cells only - PLAP -- intermed mag.jpg | GCNIS (ITGCN) & SCO - intermed. mag. | ||
Image: ITGCN and Sertoli cells only - PLAP -- high mag.jpg | ITGCN & SCO - high mag. | Image: ITGCN and Sertoli cells only - PLAP -- high mag.jpg | GCNIS (ITGCN) & SCO - high mag. | ||
Image: ITGCN and Sertoli cells only - PLAP -- very high mag.jpg | ITGCN & SCO - very high mag. | Image: ITGCN and Sertoli cells only - PLAP -- very high mag.jpg | GCNIS (ITGCN) & SCO - very high mag. | ||
</gallery> | </gallery> | ||
====www==== | ====www==== | ||
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==IHC== | ==IHC== | ||
===ISUP consensus=== | ===ISUP consensus=== | ||
ITGCN versus atypical intratubular germ cells:<ref name=pmid25025364>{{Cite journal | last1 = Amin | first1 = MB. | last2 = Epstein | first2 = JI. | last3 = Ulbright | first3 = TM. | last4 = Humphrey | first4 = PA. | last5 = Egevad | first5 = L. | last6 = Montironi | first6 = R. | last7 = Grignon | first7 = D. | last8 = Trpkov | first8 = K. | last9 = Lopez-Beltran | first9 = A. | title = Best practices recommendations in the application of immunohistochemistry in urologic pathology: report from the international society of urological pathology consensus conference. | journal = Am J Surg Pathol | volume = 38 | issue = 8 | pages = 1017-22 | month = Aug | year = 2014 | doi = 10.1097/PAS.0000000000000254 | PMID = 25025364 }}</ref> | GCNIS (ITGCN) versus atypical intratubular germ cells:<ref name=pmid25025364>{{Cite journal | last1 = Amin | first1 = MB. | last2 = Epstein | first2 = JI. | last3 = Ulbright | first3 = TM. | last4 = Humphrey | first4 = PA. | last5 = Egevad | first5 = L. | last6 = Montironi | first6 = R. | last7 = Grignon | first7 = D. | last8 = Trpkov | first8 = K. | last9 = Lopez-Beltran | first9 = A. | title = Best practices recommendations in the application of immunohistochemistry in urologic pathology: report from the international society of urological pathology consensus conference. | journal = Am J Surg Pathol | volume = 38 | issue = 8 | pages = 1017-22 | month = Aug | year = 2014 | doi = 10.1097/PAS.0000000000000254 | PMID = 25025364 }}</ref> | ||
*OCT4 +ve. | *OCT4 +ve. | ||
Alternates: | Alternates: | ||
*[[PLAP]] +ve.<ref>{{Cite journal | last1 = Schreiber | first1 = L. | last2 = Lifschitz-Mercer | first2 = B. | last3 = Paz | first3 = G. | last4 = Yavetz | first4 = H. | last5 = Elliott | first5 = DJ. | last6 = Kula | first6 = K. | last7 = Slowikowska-Hilczer | first7 = J. | last8 = Maymon | first8 = BB. | title = Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis. | journal = Int J Surg Pathol | volume = 11 | issue = 1 | pages = 17-20 | month = Jan | year = 2003 | doi = | PMID = 12598912 }}</ref> | *[[PLAP]] +ve.<ref name=pmid12598912>{{Cite journal | last1 = Schreiber | first1 = L. | last2 = Lifschitz-Mercer | first2 = B. | last3 = Paz | first3 = G. | last4 = Yavetz | first4 = H. | last5 = Elliott | first5 = DJ. | last6 = Kula | first6 = K. | last7 = Slowikowska-Hilczer | first7 = J. | last8 = Maymon | first8 = BB. | title = Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis. | journal = Int J Surg Pathol | volume = 11 | issue = 1 | pages = 17-20 | month = Jan | year = 2003 | doi = | PMID = 12598912 }}</ref> | ||
*D2-40 +ve. | *D2-40 +ve. | ||