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'''Thyroid-like follicular carcinoma of the kidney''' is a recently described rare [[kidney tumour]]. | '''Thyroid-like follicular carcinoma of the kidney''', also '''thyroid-like follicular renal cell carcinoma''' (abbreviated '''TLF-RCC''' or '''TLFRCC'''), is a recently described rare [[kidney tumour]]. | ||
It is considered an emerging entity by the ''Vancouver modification of the 2004 WHO classification of renal neoplasia''. | It is considered an emerging entity by the ''[[Vancouver classification|Vancouver modification of the 2004 WHO classification of renal neoplasia]]''.<ref name=pmid24025519>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref> | ||
==General== | ==General== | ||
*Extremely rare. | *Extremely rare - less than 15 cases reported in the literature.<ref name=pmid24025519/> | ||
*Large age range (29-83 years old). | |||
==Gross== | |||
*Solid, brown and well circumscribed. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid24025519/> | ||
*Thyroid follicule-like structures | *Thyroid follicule-like structures - both macrofollicular and/or microfollicular. | ||
**Contain dense-appearing eosinophilic material. | |||
*Encapuslated. | |||
*Nuclei round and regular with prominent nucleoli ([[ISUP nucleolar grade]] 2 or 3). | |||
DDx: | |||
*Metastatic carcinoma. | |||
**[[Follicular thyroid carcinoma]]. | |||
**[[Papillary thyroid carcinoma follicular variant]]. | |||
===Images=== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190304/figure/Fig3/ TLF-RCC (nih.gov)].<ref name=pmid25293503>{{Cite journal | last1 = Ghaouti | first1 = M. | last2 = Roquet | first2 = L. | last3 = Baron | first3 = M. | last4 = Pfister | first4 = C. | last5 = Sabourin | first5 = JC. | title = Thyroid-like follicular carcinoma of the kidney: a case report and review of the literature. | journal = Diagn Pathol | volume = 9 | issue = 1 | pages = 186 | month = | year = 2014 | doi = 10.1186/s13000-014-0186-8 | PMID = 25293503 }}</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123569/figure/fig2/ TLF-RCC (nih.gov)].<ref name=pmid25133003>{{Cite journal | last1 = Wu | first1 = WW. | last2 = Chu | first2 = JT. | last3 = Nael | first3 = A. | last4 = Rezk | first4 = SA. | last5 = Romansky | first5 = SG. | last6 = Shane | first6 = L. | title = Thyroid-like follicular carcinoma of the kidney in a young patient with history of pediatric acute lymphoblastic leukemia. | journal = Case Rep Pathol | volume = 2014 | issue = | pages = 313974 | month = | year = 2014 | doi = 10.1155/2014/313974 | PMID = 25133003 }}</ref> | |||
==IHC== | |||
Features:<ref name=pmid24025519/> | |||
*TTF-1 -ve. | |||
*Thyroglobulin -ve. | |||
*CK7 +ve/-ve. | |||
*PAX8 +ve/-ve. | |||
==See also== | ==See also== | ||
*[[Kidney tumours]]. | *[[Kidney tumours]]. | ||
*[[Thyroid gland]]. | |||
==References== | ==References== | ||
{{Reflist| | {{Reflist|1}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Kidney tumours]] | [[Category:Kidney tumours]] |
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