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Difference between revisions of "Condyloma acuminatum"
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'''Condyloma acuminatum''', also '''genital wart''', is a common benign pathology of the genital region ([[vulva]], [[penis]], perineum). | |||
==General== | |||
*Due to [[human papillomavirus]] (HPV). | |||
**Transmission: sexual, non-sexual, horizontal (mother to child).<ref name=Ref_APBR280>{{Ref APBR|280 Q29}}</ref> | |||
***Should raise the suspicion of child abuse. | |||
Note: | |||
*Related to [[verruca vulgaris]] (common wart). | |||
*The Bethesda system includes this in [[LSIL]].<ref>{{Ref GP|143}}</ref> | |||
Clinical DDx: | |||
*[[Molluscum contagiosum]].<ref>URL: [http://emedicine.medscape.com/article/781735-differential http://emedicine.medscape.com/article/781735-differential]. Accessed on: 5 July 2013.</ref> | |||
==Microscopic== | |||
Features: | |||
*Koilocytes.<ref name=pmid11860848>{{Cite journal | last1 = Huang | first1 = Z. | last2 = Yang | first2 = S. | last3 = Li | first3 = Q. | last4 = Yan | first4 = P. | last5 = Li | first5 = L. | title = [Evaluation the pathological diagnostic values of koilocyte in condyloma acuminatum]. | journal = Zhonghua Liu Xing Bing Xue Za Zhi | volume = 22 | issue = 1 | pages = 58-60 | month = Feb | year = 2001 | doi = | PMID = 11860848 }}</ref> | |||
**Cells with an enlarged nucleus and perinuclear clearing. | |||
*Papillomatosis.<ref>{{Ref WMSP|204}}</ref> | |||
**Papillomatosis = surface elevation due to dermal papillae enlargement.<ref>{{Ref PBoD|1230}}</ref> | |||
*+/-Parakeratosis. | |||
DDx: | |||
*[[Classic vulvar intraepithelial neoplasia]] - architecture different. | |||
===Images=== | |||
<gallery> | |||
Image:Condyloma_acuminatum_-_low_mag.jpg | Condyloma acuminatum - low mag. (WC) | |||
Image:Condyloma_acuminatum_-_very_high_mag.jpg | Condyloma acuminatum - very high mag. (WC) | |||
Image:Anal_condyloma_%282%29.jpg | Condyloma acuminatum - 2. (WC) | |||
Image:Anal_condyloma_%284%29.jpg | Condyloma acuminatum - 3. (WC) | |||
</gallery> | |||
==Sign out== | |||
<pre> | |||
SKIN LESION ("VULVAR WART"), VULVA, EXCISION: | |||
- CONDYLOMA ACUMINATUM (GENITAL WART). | |||
</pre> | |||
<pre> | |||
LABIA MINORA, BIOPSY: | |||
- CONDYLOMA/LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (LSIL). | |||
-- NEGATIVE FOR HIGH-GRADE DYSPLASIA. | |||
</pre> | |||
===Seborrheic keratosis-like=== | |||
<pre> | |||
Submitted as "Penile Wart", Excision: | |||
- Consistent with condyloma acuminatum (genital wart) with | |||
seborrheic keratosis-like features. | |||
</pre> | |||
====Block letters==== | |||
<pre> | |||
SKIN LESION, PERINEUM, BIOPSY: | |||
- SEBORRHEIC KERATOSIS-LIKE CONDYLOMA ACUMINATUM (GENITAL WART). | |||
</pre> | |||
===Without viral cytopathic changes=== | |||
<pre> | |||
VULVAR LESIONS (x3), EXCISION: | |||
- SQUAMOUS HYPERPLASIA WITH HYPERORTHOKERATOSIS WITHOUT VIRAL CYTOPATHIC EFFECT, | |||
COMPATIBLE WITH CONDYLOMA (x3). | |||
- NEGATIVE FOR MALIGNANCY. | |||
</pre> | |||
===Micro=== | |||
The sections show a polypoid fragment of skin with epithelium on three sides, acanthosis, hyperkeratosis and parakeratosis. Koilocytic changes (mild nuclear enlargement, perinuclear clearing) are seen focally. There is mild basilar nuclear enlargement and hyperchromasia. The epithelium shows maturation to the surface and a granular layer is present. | |||
====Seborrheic keratosis-like==== | |||
The sections show skin with acanthosis with papillomatous features (round bulbous rete ridges, acanthosis with penetrating fibrovascular cores) pseudohorn cysts, parakeratosis and hyperkeratosis. There is no significant basal nuclear atypia. There are no mitoses and no melanocytic nests. There is mild dermal inflammation. There is no solar elastosis. Pigment incontinence is present focally. | |||
==See also== | |||
*[[Vulva]]. | |||
*[[Penis]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Vulva]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||