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| Synonyms = | | Synonyms = | ||
| Micro = nests cells that have a "[[coffee bean nucleus]]" (nucleus = elliptical shape, nuclear groove along long axis), distinct nucleoli, moderate-to-abundant gray/pale cytoplasm, dense fibrous stroma around nests | | Micro = nests cells that have a "[[coffee bean nucleus]]" (nucleus = elliptical shape, nuclear groove along long axis), distinct nucleoli, moderate-to-abundant gray/pale cytoplasm, dense fibrous stroma around nests | ||
| Subtypes = | | Subtypes = benign (most common), borderline, malignant | ||
| LMDDx = [[granulosa cell tumour]], [[ovarian fibroma]], [[thecoma]] | | LMDDx = [[granulosa cell tumour]], [[ovarian fibroma]], [[thecoma]], [[Walthard cell rest]] | ||
| Stains = | | Stains = | ||
| IHC = AR +ve, calretinin -ve | | IHC = AR +ve, calretinin -ve | ||
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===Epidemiology=== | ===Epidemiology=== | ||
*Mostly benign clinical course. | *Mostly benign clinical course - 99% of Brenner tumours benign.<ref name=Ref_GP437>{{Ref GP|437}}</ref> | ||
*Thought to arise from [[Walthard cell rest]]. | *Thought to arise from [[Walthard cell rest]]. | ||
*Frequently an incidental finding, i.e. oophorectomy was done for another reason. | *Frequently an incidental finding, i.e. oophorectomy was done for another reason. | ||
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*Stromal component may be predominant. | *Stromal component may be predominant. | ||
DDx: | DDx:<ref name=Ref_GP437>{{Ref GP|437}}</ref> | ||
*Benign: | *Benign: | ||
**Endometrioid adenofibroma. | |||
**[[Ovarian fibroma]]. | **[[Ovarian fibroma]]. | ||
*Borderline: | *Borderline: | ||
**Benign Brenner tumour. | **Benign Brenner tumour. | ||
**Malignant Brenner tumour. | **Malignant Brenner tumour. | ||
**Metastatic papillary urothelial carcinoma. | **Metastatic papillary urothelial carcinoma. | ||
*Malignant: | *Malignant: | ||
**Undifferentiated carcinoma - no Brenner tumour component. | **Undifferentiated carcinoma - no Brenner tumour component. | ||
**Granulosa cell tumour. | **Granulosa cell tumour. | ||
**Serous carcinoma. | **Serous carcinoma. | ||
**Metastatic urothelial carcinoma. | **Metastatic urothelial carcinoma. | ||
*[[Walthard cell rest]] - typically one nest of cells, lacks the surrounding fibromatous stroma. | |||
===Images=== | ===Images=== | ||
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==IHC== | ==IHC== | ||
Features:<ref>{{Cite journal | last1 = Kuhn | first1 = E. | last2 = Ayhan | first2 = A. | last3 = Shih | first3 = IeM. | last4 = Seidman | first4 = JD. | last5 = Kurman | first5 = RJ. | title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. | journal = Eur J Cancer | volume = 49 | issue = 18 | pages = 3839-49 | month = Dec | year = 2013 | doi = 10.1016/j.ejca.2013.08.011 | PMID = 24012099 }}</ref> | Features:<ref name=pmid24012099>{{Cite journal | last1 = Kuhn | first1 = E. | last2 = Ayhan | first2 = A. | last3 = Shih | first3 = IeM. | last4 = Seidman | first4 = JD. | last5 = Kurman | first5 = RJ. | title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. | journal = Eur J Cancer | volume = 49 | issue = 18 | pages = 3839-49 | month = Dec | year = 2013 | doi = 10.1016/j.ejca.2013.08.011 | PMID = 24012099 }}</ref> | ||
*AR +ve. | *[[Androgen receptor|AR]] +ve. | ||
*Calretinin -ve. | *Calretinin -ve. | ||
**Surrounding stroma +ve. | **Surrounding stroma +ve. | ||
*Inhibin +ve.<ref name=pmid24012099>{{ | *Inhibin +ve.<ref name=pmid24012099>{{Cite journal | last1 = Kuhn | first1 = E. | last2 = Ayhan | first2 = A. | last3 = Shih | first3 = IeM. | last4 = Seidman | first4 = JD. | last5 = Kurman | first5 = RJ. | title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. | journal = Eur J Cancer | volume = 49 | issue = 18 | pages = 3839-49 | month = Dec | year = 2013 | doi = 10.1016/j.ejca.2013.08.011 | PMID = 24012099 }}</ref> | ||
==See also== | ==See also== |
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