Difference between revisions of "Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis"
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'''Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis''', also '''multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis''', is the presence of rare [[hamartoma]]tous lesions in the [[lung]] seen in [[tuberous sclerosis]].<ref name=pmid18234663 >{{Cite journal | last1 = Nagar | first1 = AM. | last2 = Teh | first2 = HS. | last3 = Khoo | first3 = RN. | last4 = Morani | first4 = AC. | last5 = Vrishni | first5 = K. | last6 = Raghuram | first6 = J. | title = Multifocal pneumocyte hyperplasia in tuberous sclerosis. | journal = Thorax | volume = 63 | issue = 2 | pages = 186 | month = Feb | year = 2008 | doi = 10.1136/thx.2006.076604 | PMID = 18234663 }}</ref> | '''Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis''', also '''multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis''', is the presence of rare [[hamartoma]]tous lesions in the [[lung]] seen in [[tuberous sclerosis]].<ref name=pmid18234663 >{{Cite journal | last1 = Nagar | first1 = AM. | last2 = Teh | first2 = HS. | last3 = Khoo | first3 = RN. | last4 = Morani | first4 = AC. | last5 = Vrishni | first5 = K. | last6 = Raghuram | first6 = J. | title = Multifocal pneumocyte hyperplasia in tuberous sclerosis. | journal = Thorax | volume = 63 | issue = 2 | pages = 186 | month = Feb | year = 2008 | doi = 10.1136/thx.2006.076604 | PMID = 18234663 }}</ref> | ||
==General== | ==General== | ||
*Rare. | *Rare. | ||
==Gross== | |||
Features:<ref name=pmid18535095>{{Cite journal | last1 = Kobashi | first1 = Y. | last2 = Sugiu | first2 = T. | last3 = Mouri | first3 = K. | last4 = Irei | first4 = T. | last5 = Nakata | first5 = M. | last6 = Oka | first6 = M. | title = Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis: differentiation from multiple atypical adenomatous hyperplasia. | journal = Jpn J Clin Oncol | volume = 38 | issue = 6 | pages = 451-4 | month = Jun | year = 2008 | doi = 10.1093/jjco/hyn042 | PMID = 18535095 }}</ref> | |||
*Multiple small lung nodules - apparently random distribution. | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 02:05, 8 March 2016
Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis, also multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis, is the presence of rare hamartomatous lesions in the lung seen in tuberous sclerosis.[1]
General
- Rare.
Gross
Features:[2]
- Multiple small lung nodules - apparently random distribution.
Microscopic
Features:
- Macrophages within the air spaces.
- Enlarged alveolar lining cells with:
- Hobnail morphology - free (luminal) surface area > attached/basal surface area.
- Round or oval nuclei.
DDx:
- Atypical adenomatous hyperplasia of the lung - usu. do not have macrophages within the air spaces.
Images
MMPH - intermed. mag.
MMPH - high mag.
See also
References
- ↑ Nagar, AM.; Teh, HS.; Khoo, RN.; Morani, AC.; Vrishni, K.; Raghuram, J. (Feb 2008). "Multifocal pneumocyte hyperplasia in tuberous sclerosis.". Thorax 63 (2): 186. doi:10.1136/thx.2006.076604. PMID 18234663.
- ↑ Kobashi, Y.; Sugiu, T.; Mouri, K.; Irei, T.; Nakata, M.; Oka, M. (Jun 2008). "Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis: differentiation from multiple atypical adenomatous hyperplasia.". Jpn J Clin Oncol 38 (6): 451-4. doi:10.1093/jjco/hyn042. PMID 18535095.