Sarcomatoid carcinoma of the prostate: Difference between revisions

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'''Sarcomatoid prostate carcinoma''' is a rare subtype of [[prostatic carcinoma]].
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =  Sarcomatoid_prostate_carcinoma_-_alt_--_intermed_mag.jpg
| Width      =
| Caption    = Sarcomatoid carcinoma of the prostate. [[H&E stain]].
| Synonyms  = sarcomatoid prostatic carcinoma
| Micro      =
| Subtypes  = (subtype of [[prostate carcinoma]])
| LMDDx      = [[sarcoma]], [[sarcomatoid urothelial carcinoma]]
| Stains    =
| IHC        = PSA +ve, keratin +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]]
| Staging    = [[prostate cancer staging]]
| Site      = [[prostate gland]] - see ''[[prostate carcinoma]]''
| Assdx      =
| Syndromes  = see ''[[prostate carcinoma]]''
| Clinicalhx = typically have history of conventional prostate carcinoma
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = poor
| Other      =
| ClinDDx    = see ''[[prostate carcinoma]]''
| Tx        = see ''[[prostate carcinoma]]''
}}
'''Sarcomatoid carcinoma of the prostate''', also '''sarcomatoid prostatic carcinoma''', is a rare subtype of [[prostatic carcinoma]] with histomorphologic features suggestive of a sarcoma, and a poor prognosis.


==General==
==General==
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==Microscopic==
==Microscopic==
Features:<ref name=Ref_GUP80>{{Ref GUP|77 & 80}}</ref>
Features:<ref name=Ref_GUP80>{{Ref GUP|77 & 80}}</ref>
*Biphasic tumour:
*Typically a biphasic tumour:
*#Spindle cells (sarcomatous component).
*#Spindle cells (sarcomatous component).
*#*May include components of: [[osteosarcoma]], [[chondrosarcoma]] and/or [[rhabdomyosarcoma]].
*#*May include components of: [[osteosarcoma]], [[chondrosarcoma]] and/or [[rhabdomyosarcoma]].
*#Glandular component (like conventional prostate carcinoma).
*#Epithelial (glandular) component (like conventional prostate carcinoma).
*#*May be absent. ‡
 
Note:
* ‡ The history is should be compelling or the tumour keratin positive, if no epithelial component is present. 
 
DDx:
*[[Sarcomatoid urothelial carcinoma]].
*[[Sarcoma]], e.g. [[rhabdomyosarcoma]], [[liposarcoma]], [[leiomyosarcoma]].
 
===Images===
Sarcomatoid carcinoma:
<gallery>
Image: Sarcomatoid prostate carcinoma -- low mag.jpg | SPC - low mag.
Image: Sarcomatoid prostate carcinoma -- intermed mag.jpg | SPC - intermed. mag.
Image: Sarcomatoid prostate carcinoma -- high mag.jpg | SPC - high mag.
Image: Sarcomatoid prostate carcinoma -- very high mag.jpg | SPC - very high mag.
Image: Sarcomatoid prostate carcinoma - alt -- intermed mag.jpg | SPC - intermed. mag.
Image: Sarcomatoid prostate carcinoma - alt -- high mag.jpg | SPC - high mag.
Image: Sarcomatoid prostate carcinoma - alt -- very high mag.jpg | SPC - very high mag.
</gallery>
Accompanying (conventional) prostatic carcinoma:
<gallery>
Image: Conventional prostate carcinoma -- intermed mag.jpg | SCP - intermed. mag.
Image: Conventional prostate carcinoma -- high mag.jpg | SCP - intermed. mag.
</gallery>


==IHC==
==IHC==
Retrieved from "https://librepathology.org/wiki/Sarcomatoid_carcinoma_of_the_prostate"