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Difference between revisions of "Cholestasis"
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[[Image:Cholestasis_high_mag.jpg|thumb|right|300px|Micrograph showing cholestasis, as is apparent by the yellow bile. [[H&E stain]]. (WC)]] | |||
In [[liver pathology]], '''cholestasis''' is a stoppage or abnormally slow flow of bile. | In [[liver pathology]], '''cholestasis''' is a stoppage or abnormally slow flow of bile. | ||
'''Cholestatic hepatitis''' and '''feathery degeneration''' redirect to this article. | |||
==General== | ==General== | ||
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*Dark urine and light stools. | *Dark urine and light stools. | ||
Short DDx - by etiology | ===Short DDx - by etiology=== | ||
*Congenital: Bile duct cyst, biliary atresia, liver cysts. | *Congenital: Bile duct cyst, biliary atresia, liver cysts. | ||
*Infectious: Worm. | *Infectious: Worm. | ||
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*Endocrine: cholestasis of pregnancy. | *Endocrine: cholestasis of pregnancy. | ||
*Trauma -> sepsis. | *Trauma -> sepsis. | ||
*Autoimmune: PSC, PBC. | *Autoimmune: [[primary sclerosing cholangitis|PSC]], [[primary biliary cirrhosis|PBC]]. | ||
*Toxins: alcohol -> cirrhosis. | *Toxins: [[alcoholic liver disease|alcohol]] -> [[cirrhosis]]. | ||
*Everything else: drugs, e.g. [[NSAID]]s. | *Everything else: drugs, e.g. [[NSAID]]s. | ||
Short DDx - structural | ===Short DDx - structural=== | ||
*Obstruction - large duct: | *Obstruction - large duct: | ||
**Tumour. | **Tumour. | ||
**Gallstone. | **[[Gallstone]]. | ||
**Worm. | **Worm. | ||
**PSC. | **PSC. | ||