Difference between revisions of "Oral fibroma"

From Libre Pathology
Jump to navigation Jump to search
(redirect w/ cat.)
 
 
(12 intermediate revisions by the same user not shown)
Line 1: Line 1:
#redirect [[Oral_pathology#Oral_fibroma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Oral fibroma -- very low mag.jpg
| Width      =
| Caption    = Oral fibroma. [[H&E stain]].
| Synonyms  = fibroma, focal fibrous hyperplasia, peripheral fibroma, peripheral ossifying fibroma, fibroid epulis (old term), [[fibroepithelial polyp]]
| Micro      = fibrous stroma +/-collagen bundles, prominent (dilated) vessels, overlying (squamous) mucosa benign +/-hyperkeratosis +/-focal ulceration
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = polypoid lesion, usually small
| Grossing  =
| Staging    =
| Site      = oral cavity - see ''[[oral pathology]]'' and ''[[head and neck pathology]]''
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = [[squamous papilloma]], other polypoid lesions
| Tx        = removal
}}
'''Oral fibroma''', typically referred to as simply '''[[fibroma]]''', is a very common benign lesion in [[oral pathology]].


It is also known as '''focal fibrous hyperplasia''', '''peripheral fibroma''', '''peripheral ossifying fibroma''', '''fibroid epulis''' (old term), and '''[[fibroepithelial polyp]]'''.<ref name=Ref_Sternberg5_775>{{Ref Sternberg5|775}}</ref><ref>URL: [http://emedicine.medscape.com/article/1080948-overview#aw2aab6b3 http://emedicine.medscape.com/article/1080948-overview#aw2aab6b3]. Accessed on: 20 August 2012.</ref><ref name=Ref_HaNP240>{{Ref HaNP|240}}</ref>
==General==
*Most common oral cavity tumour.<ref name=Ref_HaNP240>{{Ref HaNP|240}}</ref>
*Female predominance (female:male = 2:1), usually 30-50 years old.<ref name=Ref_HaNP240>{{Ref HaNP|240}}</ref>
*Multiple oral fibromas may be seen in [[Cowden disease]].<ref name=pmid16878060>{{Cite journal  | last1 = Segura Saint-Gerons | first1 = R. | last2 = Ceballos Salobreña | first2 = A. | last3 = Toro Rojas | first3 = M. | last4 = Gándara Rey | first4 = JM. | title = Oral manifestations of Cowden's disease. Presentation of a clinical case. | journal = Med Oral Patol Oral Cir Bucal | volume = 11 | issue = 5 | pages = E421-4 | month = Aug | year = 2006 | doi =  | PMID = 16878060 }}</ref><ref name=pmid20137749>{{Cite journal  | last1 = Oliveira | first1 = MA. | last2 = Medina | first2 = JB. | last3 = Xavier | first3 = FC. | last4 = Magalhães | first4 = M. | last5 = Ortega | first5 = KL. | title = Cowden syndrome. | journal = Dermatol Online J | volume = 16 | issue = 1 | pages = 7 | month =  | year = 2010 | doi =  | PMID = 20137749 | URL = http://dermatology.cdlib.org/1601/case_reports/cowden/ortega.html }}</ref>
*Histologically similar to [[fibrous papule]].<ref name=pmid20421776>{{Cite journal  | last1 = Fernandez-Flores | first1 = A. | title = Solitary oral fibromas of the tongue show similar morphologic features to fibrous papule of the face: a study of 31 cases. | journal = Am J Dermatopathol | volume = 32 | issue = 5 | pages = 442-7 | month = Jul | year = 2010 | doi = 10.1097/DAD.0b013e3181c47142 | PMID = 20421776 }}</ref>
Clinical DDx:
*[[Squamous papilloma]].
==Microscopic==
Features:<ref name=pmid20421776/>
*Fibrous stroma - '''key feature'''.
**"Very pink" at low power.
*+/-Collagen bundles, may be prominent.
*Prominent (dilated) vessels.
*Overlying (squamous) mucosa benign (flat).
**+/-Hyperkeratosis +/-focal ulceration.<ref name=Ref_HaNP240>{{Ref HaNP|240}}</ref>
===Images===
<gallery>
Image: Oral fibroma -- very low mag.jpg | OF - very low mag. (WC)
Image: Oral fibroma -- low mag.jpg | OF - low mag. (WC)
Image: Oral fibroma -- intermed mag.jpg | OF - intermed. mag. (WC)
</gallery>
==Sign out==
<pre>
Lower Buccal Lesion, Left, Excision:
- Fibroma.
- NEGATIVE for malignancy.
</pre>
<pre>
Left Tongue Lesion, Excision:
- Fibroma with overlying squamous epithelium with parakeratosis.
- NEGATIVE for malignancy.
</pre>
====Block letters====
<pre>
TONGUE LESION, BIOPSY:
- FIBROMA.
</pre>
===Micro===
The sections show a polypoid fragment of squamous mucosa with a thin layer of parakeratosis. The subepithelial tissue consists of abundant fibrous tissue and has dilated small blood vessels. 
No significant inflammation is present. No nuclear atypia is apparent. No necrosis is present. No proliferative activity is apparent.
==See also==
*[[Oral pathology]].
*[[Fibroma]].
==References==
{{Reflist|2}}
[[Category:Oral pathology]]
[[Category:Head and neck pathology]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 19:10, 3 February 2016

Oral fibroma
Diagnosis in short

Oral fibroma. H&E stain.
Synonyms fibroma, focal fibrous hyperplasia, peripheral fibroma, peripheral ossifying fibroma, fibroid epulis (old term), fibroepithelial polyp
LM fibrous stroma +/-collagen bundles, prominent (dilated) vessels, overlying (squamous) mucosa benign +/-hyperkeratosis +/-focal ulceration
Gross polypoid lesion, usually small
Site oral cavity - see oral pathology and head and neck pathology
Prevalence very common
Prognosis benign
Clin. DDx squamous papilloma, other polypoid lesions
Treatment removal

Oral fibroma, typically referred to as simply fibroma, is a very common benign lesion in oral pathology.

It is also known as focal fibrous hyperplasia, peripheral fibroma, peripheral ossifying fibroma, fibroid epulis (old term), and fibroepithelial polyp.[1][2][3]

General

  • Most common oral cavity tumour.[3]
  • Female predominance (female:male = 2:1), usually 30-50 years old.[3]

Clinical DDx:

Microscopic

Features:[6]

  • Fibrous stroma - key feature.
    • "Very pink" at low power.
  • +/-Collagen bundles, may be prominent.
  • Prominent (dilated) vessels.
  • Overlying (squamous) mucosa benign (flat).
    • +/-Hyperkeratosis +/-focal ulceration.[3]

Images

  • OF - very low mag. (WC)

  • OF - low mag. (WC)

  • OF - intermed. mag. (WC)

Sign out

Lower Buccal Lesion, Left, Excision:
- Fibroma.
- NEGATIVE for malignancy.

Left Tongue Lesion, Excision:
- Fibroma with overlying squamous epithelium with parakeratosis.
- NEGATIVE for malignancy.

Block letters

TONGUE LESION, BIOPSY:
- FIBROMA.

Micro

The sections show a polypoid fragment of squamous mucosa with a thin layer of parakeratosis. The subepithelial tissue consists of abundant fibrous tissue and has dilated small blood vessels.

No significant inflammation is present. No nuclear atypia is apparent. No necrosis is present. No proliferative activity is apparent.

See also

References

  1. ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Reuter, Victor E; Stoler, Mark H (2009). Sternberg's Diagnostic Surgical Pathology (5th ed.). Lippincott Williams & Wilkins. pp. 775. ISBN 978-0781779425.
  2. ↑ URL: http://emedicine.medscape.com/article/1080948-overview#aw2aab6b3. Accessed on: 20 August 2012.
  3. ↑ 3.0 3.1 3.2 3.3 Thompson, Lester D. R. (2006). Head and Neck Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 240. ISBN 978-0443069604.
  4. ↑ Segura Saint-Gerons, R.; Ceballos Salobreña, A.; Toro Rojas, M.; Gándara Rey, JM. (Aug 2006). "Oral manifestations of Cowden's disease. Presentation of a clinical case.". Med Oral Patol Oral Cir Bucal 11 (5): E421-4. PMID 16878060.
  5. ↑ Oliveira, MA.; Medina, JB.; Xavier, FC.; Magalhães, M.; Ortega, KL. (2010). "Cowden syndrome.". Dermatol Online J 16 (1): 7. PMID 20137749.
  6. ↑ 6.0 6.1 Fernandez-Flores, A. (Jul 2010). "Solitary oral fibromas of the tongue show similar morphologic features to fibrous papule of the face: a study of 31 cases.". Am J Dermatopathol 32 (5): 442-7. doi:10.1097/DAD.0b013e3181c47142. PMID 20421776.
Retrieved from "https://librepathology.org/w/index.php?title=Oral_fibroma&oldid=42413"