Difference between revisions of "Celiac sprue"

Celiac sprue (view source)

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 ==Microscopic==
 Features:<ref name=Ref_PBoD843>{{Ref PBoD|843}}</ref>
-*Intraepithelial lymphocytes - '''key feature'''.
+*Intraepithelial lymphocytes (IELs) - '''key feature'''.
 **Should be more pronounced at tips of villi.<ref name=pmid15280404>{{cite journal |author=Biagi F, Luinetti O, Campanella J, ''et al.'' |title=Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? |journal=J. Clin. Pathol. |volume=57 |issue=8 |pages=835–9 |year=2004 |month=August |pmid=15280404 |pmc=1770380 |doi=10.1136/jcp.2003.013607 |url=}}</ref>
+**Criteria for number varies:
+*** > 40 IELs / 100 epithelial cells.<ref name=pmid10524652>{{cite journal |author=Oberhuber G, Granditsch G, Vogelsang H |title=The histopathology of coeliac disease: time for a standardized report scheme for pathologists |journal=Eur J Gastroenterol Hepatol |volume=11 |issue=10 |pages=1185–94 |year=1999 |month=October |pmid=10524652 |doi= |url=}}</ref>
+*** > 25 IELs / 100 enterocytes.<ref name=pmid17544877>{{cite journal |author=Corazza GR, Villanacci V, Zambelli C, ''et al.'' |title=Comparison of the interobserver reproducibility with different histologic criteria used in celiac disease |journal=Clin. Gastroenterol. Hepatol. |volume=5 |issue=7 |pages=838–43 |year=2007 |month=July |pmid=17544877 |doi=10.1016/j.cgh.2007.03.019 |url=}}</ref>
 *Loss of villi - '''important feature'''.
 **Normal duodenal biopsy should have 3 good villi.