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| =Liver biopsy= | | =Liver biopsy= |
| ==Medical liver biopsy adequacy== | | ==Medical liver biopsy adequacy== |
| Liver biopsy specimens should be:<ref>{{Ref MacSween|418}}</ref>
| | *This is covered in the ''[[Medical_liver_disease#Medical_liver_biopsy_adequacy|Medical liver disease]]'' article. |
| *2.0 cm in length and contain 11-15 portal tracts, | |
| *The core should be deeper than 1.0 cm from the liver capsule; specimens close to the capsule may lead to over grading of fibrosis.
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| ==Reporting== | | ==Reporting== |
| {{Main|Pathology reports}} | | {{Main|Pathology reports}} |
| <pre>
| | *This is covered in the ''[[Medical_liver_disease#Reporting|Medical liver disease]]'' article. |
| Specimen, procedure:
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| - Diagnosis.
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| </pre>
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| The diagnosis usually contains grading and staging information, e.g. ''activity 2 /4, Laennec fibrosis stage 1 /4''.
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| In the context of medical liver disease:
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| *Grade = inflammation/activity. | |
| *Stage = severity of fibrosis/architectural changes.
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| Notes:
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| *The term "acute" is infrequently used in liver pathology.
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| *In the liver: neutrophils ''is not'' acute -- unlike most elsewhere in the body.<ref>OA. September 2009.</ref>
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| ===A microscopic checklist===
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| <pre>
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| Size of biopsy: Adequate
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| Fragmentation: Absent
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| Fibrosis: Stage 2-3/4, mostly stage 2
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| Fibrous septa: Present
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| Septa with curved contours: Present – focally only
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| Large droplet steatosis (% of hepatocytes): Present, moderate 60%
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| Ballooning of hepatocytes: Present, rare
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| Mallory-Denk bodies: Present, rare
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| Portal inflammation: Present
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| Interface activity: Minimal (0-1/4)
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| Lobular necroinflammation: Minimal
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| Ducts: Present in normal numbers
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| Duct injury: Absent
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| Ductular reaction: Absent
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| Cholestasis: Absent
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| Terminal hepatic venules: Present
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| Iron stain: Absent
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| Ground glass cells with routine stains: Absent
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| PASD for alpha-1 antitrypsin droplets: Negative
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| </pre>
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| =Liver injury terms/histologic findings= | | =Liver injury terms/histologic findings= |