Difference between revisions of "Liver pathology"

Jump to navigation Jump to search
1,203 bytes removed ,  04:50, 4 January 2016
Line 116: Line 116:
=Liver biopsy=
=Liver biopsy=
==Medical liver biopsy adequacy==
==Medical liver biopsy adequacy==
Liver biopsy specimens should be:<ref>{{Ref MacSween|418}}</ref>
*This is covered in the ''[[Medical_liver_disease#Medical_liver_biopsy_adequacy|Medical liver disease]]'' article.
*2.0 cm in length and contain 11-15 portal tracts,
*The core should be deeper than 1.0 cm from the liver capsule; specimens close to the capsule may lead to over grading of fibrosis.


==Reporting==
==Reporting==
{{Main|Pathology reports}}
{{Main|Pathology reports}}
<pre>
*This is covered in the ''[[Medical_liver_disease#Reporting|Medical liver disease]]'' article.
Specimen, procedure:
- Diagnosis.
</pre>
The diagnosis usually contains grading and staging information, e.g. ''activity 2 /4, Laennec fibrosis stage 1 /4''.
 
In the context of medical liver disease:
*Grade = inflammation/activity.
*Stage = severity of fibrosis/architectural changes.
 
Notes:
*The term "acute" is infrequently used in liver pathology.
*In the liver: neutrophils ''is not'' acute -- unlike most elsewhere in the body.<ref>OA. September 2009.</ref>
 
===A microscopic checklist===
<pre>
Size of biopsy: Adequate
Fragmentation: Absent
Fibrosis: Stage 2-3/4, mostly stage 2
Fibrous septa: Present
Septa with curved contours: Present – focally only
Large droplet steatosis (% of hepatocytes): Present, moderate 60%
Ballooning of hepatocytes: Present, rare
Mallory-Denk bodies: Present, rare
Portal inflammation: Present
Interface activity: Minimal (0-1/4)
Lobular necroinflammation: Minimal
Ducts: Present in normal numbers
Duct injury: Absent
Ductular reaction: Absent
Cholestasis: Absent
Terminal hepatic venules: Present
Iron stain: Absent
Ground glass cells with routine stains: Absent
PASD for alpha-1 antitrypsin droplets: Negative
</pre>


=Liver injury terms/histologic findings=
=Liver injury terms/histologic findings=
48,790

edits

Navigation menu