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Difference between revisions of "Small round cell tumours"
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Small round cell tumours (view source)
Revision as of 21:18, 28 February 2011
, 21:18, 28 February 2011+ref, tweak
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It is a group of tumours that is seen more often in childhood than adulthood. | It is a group of tumours that is seen more often in childhood than adulthood. | ||
DDx:<ref>URL: [http://www.thedoctorsdoctor.com/diseases/small_round_blue_cell_tumor.htm http://www.thedoctorsdoctor.com/diseases/small_round_blue_cell_tumor.htm]. Accessed on: 2 July 2010.</ref> | DDx:<ref>URL: [http://www.thedoctorsdoctor.com/diseases/small_round_blue_cell_tumor.htm http://www.thedoctorsdoctor.com/diseases/small_round_blue_cell_tumor.htm]. Accessed on: 2 July 2010.</ref><ref>{{cite journal |author=Chen QR, Vansant G, Oades K, ''et al.'' |title=Diagnosis of the small round blue cell tumors using multiplex polymerase chain reaction |journal=J Mol Diagn |volume=9 |issue=1 |pages=80–8 |year=2007 |month=February |pmid=17251339 |pmc=1867426 |doi=10.2353/jmoldx.2007.060111 |url=}}</ref> | ||
*[[Neuroblastoma]]. | *[[Neuroblastoma]]. | ||
*[[Wilms tumour]] ([[AKA]] nephroblastoma). | *[[Wilms tumour]] ([[AKA]] nephroblastoma). | ||
*Alveolar [[rhabdomyosarcoma]]. | *Alveolar [[rhabdomyosarcoma]]. | ||
*[[Ewing sarcoma]]/PNET - this entity is dealt with in the ''[[bone tumours]]'' article. | *[[Ewing sarcoma]]/PNET - this entity is dealt with in the ''[[bone tumours]]'' article. | ||
*[[Lymphoma]] - large cell lymphomas | *[[Lymphoma]] - non-Hogkin's lymphoma, usu. large cell lymphomas (e.g. [[diffuse large B cell lymphoma]], anaplastic large cell lymphoma), Burkitt's lymphoma. | ||
*[[Retinoblastoma]]. | *[[Retinoblastoma]]. | ||
*[[Liver neoplasms|Hepatoblastoma]]. | *[[Liver neoplasms|Hepatoblastoma]]. | ||
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| PAS+/PASD-, CD99 diffuse membranous | | PAS+/PASD-, CD99 diffuse membranous | ||
|- | |- | ||
| | | Alveolar rhabdomyosarcoma | ||
| rhabdomyocytes (eosinophilic cytoplasm +/-cross striations (uncommon), eccentric nucleus) | | rhabdomyocytes (eosinophilic cytoplasm +/-cross striations (uncommon), eccentric nucleus) | ||
| adolescents, young adults; often mets at presentation | | adolescents, young adults; often mets at presentation | ||
| "DAM" = desmin, actin, myogenin | | "DAM" = desmin, actin, myogenin | ||
|- | |- | ||
| | | Embryonal rhabdomyosarcoma | ||
| rhabdomyocytes (elongated/cigar-shaped cells, eosinophilic cytoplasm +/-cross striations, eccentric nucleus), nests with rounded border | | rhabdomyocytes (elongated/cigar-shaped cells, eosinophilic cytoplasm +/-cross striations, eccentric nucleus), nests with rounded border | ||
| <10 years old; usu. localized | | <10 years old; usu. localized | ||
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| synaptophysin, chromogranin, CD56, keratins | | synaptophysin, chromogranin, CD56, keratins | ||
|- | |- | ||
| [[Lymphoma]] | | [[Lymphoma]], non-Hogkin's, usu. large cell | ||
| dyscohesive cells, ~2x normal (resting) lymphocyte, nucleolus | | dyscohesive cells, usu. ~2x normal (resting) lymphocyte, usu. nucleolus | ||
| lymphadenopathy (???) | | lymphadenopathy (???) | ||
| CD45 | | CD45 | ||