Difference between revisions of "Ballooning degeneration"

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#redirect [[Liver_pathology#Ballooning_degeneration]]
'''Ballooning degeneration''' is a histomorphologic change seen in [[liver pathology]]. It is indicative of [[steatohepatitis]].<ref name=pmid14585234>{{Cite journal  | last1 = Liangpunsakul | first1 = S | last2 = Chalasani | first2 = N | title = Treatment of Nonalcoholic Fatty Liver Disease. | journal = Curr Treat Options Gastroenterol | volume = 6 | issue = 6 | pages = 455-463 | month = Dec | year = 2003 | doi =  | PMID = 14585234 }}</ref>
 
==General==
*A form of apoptosis.<ref name=pmid17355088>{{Cite journal  | last1 = Yip | first1 = WW | last2 = Burt | first2 = AD | title = Alcoholic liver disease. | journal = Semin Diagn Pathol | volume = 23 | issue = 3-4 | pages = 149–60 | month =  | year =  2006| doi =  10.1053/j.semdp.2006.11.002| pmid = 17355088 }}</ref>
 
==Microscopic==
Features:
*Central nucleus.
**"Fat cells" have peripheral nucleus.
*Cytoplasm cleared with "whisps" or cobbwebs.
*Large relative to normal hepatocyte.
**2-3X normal size.<ref>Guindi, M. 16 September 2009.</ref>
 
Notes:
*The term is used only in conjunction with ''[[steatohepatitis]]''.
*''[[Feathery degeneration]]'' is the term used in the context of cholestasis.
**It is usually periportal.
 
DDx:
*[[Feathery degeneration]] - has noticable bile.
 
===Images===
<gallery>
Image:Ballooning_degeneration_high_mag_cropped.jpg | Ballooning degeneration. (WC/Nephron)
</gallery>
www:
*[http://www.uthscsa.edu/hscnews/EnlargePicture.asp?PicName=LiverBeforeTreatment_BODY.jpg Ballooning degeneration (uthscsa.edu)].
*[http://library.med.utah.edu/WebPath/LIVEHTML/LIVER039.html Ballooning degeneration (med.utah.edu)].
 
==See also==
*[[Feathery degeneration]].
*[[Steatohepatitis]].
*[[Steatosis]].
 
==References==
{{Reflist|2}}
 
[[Category:Liver pathology]]

Revision as of 22:25, 3 January 2016

Ballooning degeneration is a histomorphologic change seen in liver pathology. It is indicative of steatohepatitis.[1]

General

  • A form of apoptosis.[2]

Microscopic

Features:

  • Central nucleus.
    • "Fat cells" have peripheral nucleus.
  • Cytoplasm cleared with "whisps" or cobbwebs.
  • Large relative to normal hepatocyte.
    • 2-3X normal size.[3]

Notes:

DDx:

Images

www:

See also

References

  1. Liangpunsakul, S; Chalasani, N (Dec 2003). "Treatment of Nonalcoholic Fatty Liver Disease.". Curr Treat Options Gastroenterol 6 (6): 455-463. PMID 14585234.
  2. Yip, WW; Burt, AD (2006). "Alcoholic liver disease.". Semin Diagn Pathol 23 (3-4): 149–60. doi:10.1053/j.semdp.2006.11.002. PMID 17355088.
  3. Guindi, M. 16 September 2009.