Eccrine spiradenoma: Difference between revisions

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*Biphasic cell population:
*Biphasic cell population:
**outer dark cells with small hyperchromatic nuclei and minimal cytoplasm.
**outer dark cells with small hyperchromatic nuclei and minimal cytoplasm.
**inner larger cells with vesicular nuclei and more cytoplasm.
**inner larger cells with [[vesicular nuclei]] and more cytoplasm.
**In some areas the two cell types mix together with dispersed hyaline droplets.
**In some areas the two cell types mix together with dispersed hyaline droplets.
*Ductal differentiation.
*Ductal differentiation.
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DDx:
DDx:
*[[Dermal cylindroma]]-
*[[Dermal cylindroma]].
**These two tumors are very closely related and overlap.
**These two tumors are very closely related and overlap.
**Many tumors have areas of both spiradenoma and cylindroma.
**Many tumors have areas of both spiradenoma and cylindroma.
**The lobules of cylindroma are  
**The lobules of cylindroma are small
***more consistently discrete,  
***more consistently discrete,  
***show more a more consistent arrangement of the light and dark cells and are
***show more a more consistent arrangement of the light and dark cells and are
***surrounded by prominent hyaline material.
***often surrounded by prominent hyaline material.
**Individual lobules of cylindroma fit together like pieces of a puzzle.
**Individual lobules of cylindroma fit together like pieces of a puzzle.
**Lobules of spiradenoma  
**Lobules of spiradenoma are larger
***may run together and fuse,  
***may run together and fuse,  
***may not have a prominent hyaline surround and
***may not have a prominent hyaline surround and
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**Spiradenoma lacks clefting artefact.
**Spiradenoma lacks clefting artefact.
**Spiradenoma lacks mitoses and prominent apoptosis.
**Spiradenoma lacks mitoses and prominent apoptosis.
**BCC lacks ducts
**BCC lobules lack a prominent surrounding hyaline membrane
*Lymphoid aggregate (spiradenoma will be cytokeratin positive)
*Lymphoid aggregate (spiradenoma will be cytokeratin positive)


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*S100 +ve.
*S100 +ve.
*Keratins 7, 8, and 18 +ve.
*Keratins 7, 8, and 18 +ve.
*Ductules are EMA and CEA positive.
*Ductules are [[EMA]] and [[CEA]] positive.
Notes:
Notes:
*IHC profile essentially identical to dermal cylindroma.<ref name=pmid9129700/>
*IHC profile essentially identical to dermal cylindroma.<ref name=pmid9129700/>
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