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Prostate cancer grading (view source)
Revision as of 07:20, 30 December 2015
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==Gleason grading system== | ==Gleason grading system== | ||
*[[AKA]] ''modified Gleason grading system''. | *[[AKA]] ''modified Gleason grading system''. | ||
===Overview=== | ===Overview=== | ||
*This system is only one any one talks about and there is consensus on how it is done.<ref name=pmid16096414>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Allsbrook | first2 = WC. | last3 = Amin | first3 = MB. | last4 = Egevad | first4 = LL. | title = The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. | journal = Am J Surg Pathol | volume = 29 | issue = 9 | pages = 1228-42 | month = Sep | year = 2005 | doi = | PMID = 16096414 }}</ref> | *This system is only one any one talks about and there is consensus on how it is done.<ref name=pmid16096414>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Allsbrook | first2 = WC. | last3 = Amin | first3 = MB. | last4 = Egevad | first4 = LL. | title = The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. | journal = Am J Surg Pathol | volume = 29 | issue = 9 | pages = 1228-42 | month = Sep | year = 2005 | doi = | PMID = 16096414 }}</ref> | ||
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*A prostatectomy with 80% pattern 4, 16% pattern 3 and 4% pattern 5... would be reported as: 4+3=7 with tertiary pattern 5. | *A prostatectomy with 80% pattern 4, 16% pattern 3 and 4% pattern 5... would be reported as: 4+3=7 with tertiary pattern 5. | ||
===Gleason patterns (modified)=== | ===Gleason patterns (modified)=== | ||
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versus 4+3 on core biopsy) may be explained by sampling. | versus 4+3 on core biopsy) may be explained by sampling. | ||
</pre> | </pre> | ||
==Grade groupings== | |||
*[[AKA]] ''prognostic Gleason grade groupings''. | |||
Proposed new system and old (modified) Gleason score:<ref name=jhu2014>URL: [http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php]. Accessed on: 28 March 2015.</ref><ref name=pmid26166626>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Zelefsky | first2 = MJ. | last3 = Sjoberg | first3 = DD. | last4 = Nelson | first4 = JB. | last5 = Egevad | first5 = L. | last6 = Magi-Galluzzi | first6 = C. | last7 = Vickers | first7 = AJ. | last8 = Parwani | first8 = AV. | last9 = Reuter | first9 = VE. | title = A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score. | journal = Eur Urol | volume = | issue = | pages = | month = Jul | year = 2015 | doi = 10.1016/j.eururo.2015.06.046 | PMID = 26166626 }}</ref> | |||
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | |||
! Prognostic group | |||
! Gleason score | |||
|- | |||
| I | |||
| 3+3 | |||
|- | |||
| II | |||
| 3+4 | |||
|- | |||
| III | |||
| 4+3 | |||
|- | |||
| IV | |||
| 8 (4+4, 3+5, 5+3) | |||
|- | |||
| V | |||
| 9 or 10 (4+5, 5+4, 5+5) | |||
|} | |||
Rationale: | |||
*Patients won't be told they have a 6 out of 10 cancer, and then think it is an intermediate grade cancer that is worrisome. Instead, they will be told they have a 1 out of 5 cancer.<ref name=jhu2014>URL: [http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php]. Accessed on: 28 March 2015.</ref> | |||
==See also== | ==See also== | ||